Santos Regiane R, Oosterveer-van der Doelen Marjolein A M, Tersteeg-Zijderveld Monique H G, Molist Francesc, Mézes Miklós, Gehring Ronette
Schothorst Feed Research, 8200 AM Lelystad, The Netherlands.
Veterinary Pharmacotherapy and Pharmacy, Department of Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104-106, 3584 CM Utrecht, The Netherlands.
Animals (Basel). 2021 Apr 1;11(4):989. doi: 10.3390/ani11040989.
Multi-mycotoxin contamination of poultry diets is a recurrent problem, even if the mycotoxins levels are below EU recommendations. Deoxynivalenol (DON) is one of the main studied mycotoxins due to its risks to animal production and health. When evaluating the effects of DON, one must consider that under practical conditions diets will not be contaminated solely with this mycotoxin. In the present study, broiler chickens were fed diets with negligible mycotoxin levels or with naturally or artificially contaminated diets containing approximately 4000 μg/kg DON. Birds were sampled at D14 and D28. Naturally-contaminated diets caused the most harm to the birds, especially the young ones, which presented decreased jejunal villus height and increased lesions, down-regulation of a peptide transporter. At D28 broiler chickens seemed to have adapted to the dietary conditions, when no differences were observed in villus morphometry, together with up-regulation of a carbohydrate transporter. However, intestinal lesions remained present in these older birds.
家禽日粮的多霉菌毒素污染是一个反复出现的问题，即使霉菌毒素水平低于欧盟建议值。由于脱氧雪腐镰刀菌烯醇（DON）对动物生产和健康存在风险，它是主要研究的霉菌毒素之一。在评估DON的影响时，必须考虑到在实际条件下，日粮不会仅受这种霉菌毒素污染。在本研究中，给肉鸡饲喂霉菌毒素水平可忽略不计的日粮，或含有约4000μg/kg DON的天然或人工污染日粮。在第14天和第28天对鸡进行采样。天然污染的日粮对鸡造成的危害最大，尤其是幼鸡，表现为空肠绒毛高度降低、病变增加以及一种肽转运体的下调。在第28天，肉鸡似乎已适应日粮条件，此时在绒毛形态测量方面未观察到差异，同时一种碳水化合物转运体上调。然而，这些较大的鸡仍存在肠道病变。
