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α-氯醛糖的毒性作用。

The toxic effects of alpha-chloralose.

作者信息

Thomas H M, Simpson D, Prescott L F

机构信息

Regional Poisoning Treatment Centre, Royal Infirmary, Edinburgh, UK.

出版信息

Hum Toxicol. 1988 May;7(3):285-7. doi: 10.1177/096032718800700311.

DOI:10.1177/096032718800700311
PMID:3391628
Abstract
  1. Alpha-chloralose, formed by the condensation of glucose with chloral, is used as a rodenticide and in the control of bird pests. 2. In two cases of poisoning with alpha-chloralose the clinical features included coma and generalized convulsions resembling the effects of strychnine more than those of chloral hydrate. 3. The principles of management are the support of vital functions in the unconscious patient and removal of unabsorbed poison by gastric lavage. Diazepam may be used to control convulsions.
摘要
  1. 由葡萄糖与水合氯醛缩合形成的α-氯醛糖用作灭鼠剂及防治鸟类害虫。2. 在两例α-氯醛糖中毒病例中，临床特征包括昏迷和全身性惊厥，与士的宁中毒的效应相似，而与水合氯醛中毒的效应不同。3. 处理原则是维持昏迷患者的生命功能，并通过洗胃清除未吸收的毒物。可使用地西泮控制惊厥。

相似文献

1
The toxic effects of alpha-chloralose.α-氯醛糖的毒性作用。
Hum Toxicol. 1988 May;7(3):285-7. doi: 10.1177/096032718800700311.
2
Suspected seizure-survival of a lethal dose of the rodenticide alpha-chloralose.疑似摄入致死剂量灭鼠药α-氯醛糖后的癫痫发作存活情况
Anaesthesist. 2019 Dec;68(12):843-847. doi: 10.1007/s00101-019-00692-7. Epub 2019 Nov 7.
3
1H NMR spectroscopy and GC-MS analysis of alpha-chloralose. Application to two poisoning cases.α-氯醛糖的¹H核磁共振光谱法和气相色谱-质谱联用分析。应用于两起中毒案例。
J Anal Toxicol. 2003 Apr;27(3):156-61. doi: 10.1093/jat/27.3.156.
4
[Voluntary chloralose poisoning].
Cah Anesthesiol. 1985 Nov;33(7):589-92.
5
[Acute poisonings and convulsive crises. Electroencephalographic study of 3 very different products: Rimifon, chloralose, metaldehyde].
Rev Neurol (Paris). 1967 Sep;117(3):495-8.
6
[Clinical and electroencephalographic aspects of acute drug poisoning with chloralose. Apropos of 11 recent cases].
Rev Neurol (Paris). 1970 Oct;123(4):268-72.
7
Alpha-chloralose poisoning in dogs and cats: a retrospective study of 33 canine and 13 feline confirmed cases.犬猫α-氯醛糖中毒：33例犬和13例猫确诊病例的回顾性研究
Vet J. 2006 Jul;172(1):109-13. doi: 10.1016/j.tvjl.2005.02.030.
8
[Chloralose poisoning].
Presse Med. 1986 Jun 14;15(24):1158.
9
Clinical and EEG features of acute drug intoxication with chloralose in eleven recent cases.
Electroencephalogr Clin Neurophysiol. 1971 Apr;30(4):374.
10
[Graded classification of acute chloralose poisoning. 509 cases].
Presse Med. 2001;30(21):1055-8.

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Alpha-chloralose poisoning in cats in three Nordic countries - the importance of secondary poisoning.北欧三国的猫 alpha-三氯蔗糖中毒——二次中毒的重要性。
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Alpha-chloralose poisoning in cats: clinical findings in 25 confirmed and 78 suspected cases.
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Development and Validation of a Quantitative UHPLC-MS-MS Method for the Determination of Alpha-Chloralose in Feline Blood and Application on Blood Samples Collected from Cats with Symptoms of Alpha-Chloralose Poisoning.建立并验证一种用于检测猫血液中氯醛糖的超高效液相色谱-串联质谱法，并应用于检测疑似氯醛糖中毒的猫的血液样本。
J Anal Toxicol. 2022 Jul 14;46(6):651-657. doi: 10.1093/jat/bkab087.
5
Suspected seizure-survival of a lethal dose of the rodenticide alpha-chloralose.疑似摄入致死剂量灭鼠药α-氯醛糖后的癫痫发作存活情况
Anaesthesist. 2019 Dec;68(12):843-847. doi: 10.1007/s00101-019-00692-7. Epub 2019 Nov 7.
6
Functional brain mapping using specific sensory-circuit stimulation and a theoretical graph network analysis in mice with neuropathic allodynia.使用特定感觉回路刺激和理论图网络分析在神经病理性痛觉过敏的小鼠中进行功能性脑映射。
Sci Rep. 2016 Nov 29;6:37802. doi: 10.1038/srep37802.
7
Poisoning in children 4: household products, plants, and mushrooms.儿童中毒4：家用产品、植物和蘑菇。
Arch Dis Child. 2002 Nov;87(5):403-6. doi: 10.1136/adc.87.5.403.
8
Trichloroethanol is not a metabolite of alpha chloralose.三氯乙醇不是α-氯醛糖的代谢产物。
Int J Legal Med. 1996;108(4):191-3. doi: 10.1007/BF01369790.
9
Unrecognised chloralose poisoning.
Intensive Care Med. 1992;18(8):497. doi: 10.1007/BF01708591.