Si Jing, Zhang Haidi, Zhu Lina, Chen Aiguo
College of Physical Education, Yangzhou University, Yangzhou 225127, China.
School of Physical Education and Sports Science, Beijing Normal University, Beijing 100875, China.
Life (Basel). 2021 Apr 3;11(4):313. doi: 10.3390/life11040313.
The main aim of this study was to explore the association between overweight/obesity and executive control (EC) in young adults, and to further analyze the mediating effect of brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine (5-HT)) on the relationship between overweight/obesity and EC. A total of 449 college students aged between 18 and 20 years were recruited for the study between March and December 2019. Their height and weight were then measured professionally. Subsequently, body mass index (BMI) was calculated as weight (kg) divided by the square of height (m). The EC of the participants was then estimated using the Flanker task, while their serum BDNF levels and 5-HT levels were measured using an enzyme-linked immunosorbent assay (ELISA) kit. Finally, the multiple intermediary models in SPSS were used to analyze the mediating effect of 5-HT and BDNF between overweight/obesity and EC. The result show that the overweight/obesity of college students was positively correlated with the response of EC ( ≤ 0.005). However, it was negatively correlated with BDNF ( ≤ 0.05) and 5-HT ( ≤ 0.05). Moreover, BDNF ( ≤ 0.001) and 5-HT ( ≤ 0.001) were negatively correlated with the response of EC. The BDNF level played a partial mediating role between overweight/obesity and EC that accounted for 7.30% of the total effect value. Similarly, the 5-HT of college students played a partial mediating role between overweight/obesity and EC that accounted for 8.76% of the total effect value. Gender and age had no regulatory effect on the relationship between overweight/obesity, BDNF, 5-HT, and EC. This study provides the evidence that 5-HT and BDNF mediated the association between overweight/obesity and executive control. It is indicated that 5-HT and BDNF might be the biological pathways underpinning the link between overweight/obesity and executive control.
本研究的主要目的是探讨年轻成年人中超重/肥胖与执行控制（EC）之间的关联，并进一步分析脑源性神经营养因子（BDNF）和血清素（5-羟色胺（5-HT））在超重/肥胖与EC关系中的中介作用。2019年3月至12月期间，共招募了449名年龄在18至20岁之间的大学生参与本研究。随后对他们的身高和体重进行了专业测量。接着，计算体重指数（BMI），即体重（千克）除以身高（米）的平方。然后使用Flanker任务评估参与者的EC，同时使用酶联免疫吸附测定（ELISA）试剂盒测量他们的血清BDNF水平和5-HT水平。最后，使用SPSS中的多重中介模型分析5-HT和BDNF在超重/肥胖与EC之间的中介作用。结果显示，大学生的超重/肥胖与EC反应呈正相关（≤0.005）。然而，它与BDNF（≤0.05）和5-HT（≤0.05）呈负相关。此外，BDNF（≤0.001）和5-HT（≤0.001）与EC反应呈负相关。BDNF水平在超重/肥胖与EC之间起部分中介作用，占总效应值的7.30%。同样，大学生的5-HT在超重/肥胖与EC之间起部分中介作用，占总效应值的8.76%。性别和年龄对超重/肥胖、BDNF、5-HT和EC之间的关系没有调节作用。本研究提供了证据表明5-HT和BDNF介导了超重/肥胖与执行控制之间的关联。这表明5-HT和BDNF可能是超重/肥胖与执行控制之间联系的生物学途径。
