Su Chia-Ming, Rowland Raymond Robert Richard, Yoo Dongwan
Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
Vaccines (Basel). 2021 Apr 7;9(4):354. doi: 10.3390/vaccines9040354.
Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and understanding of the entry of PRRSV into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand for the control of PRRS.
细胞受体在病毒感染中起着关键作用。至少有七种细胞分子已被确定为猪繁殖与呼吸综合征病毒（PRRSV）的假定病毒进入介质。越来越多的数据表明，在这些候选分子中，巨噬细胞上富含半胱氨酸的清道夫受体CD163是PRRSV的主要受体。本文综述了PRRSV进入细胞的最新进展和认识、CD163基因编辑猪的病毒发病机制以及CD163作为控制PRRS的受体-配体潜在靶点的研究情况。
