Pancu Daniel Florin, Scurtu Alexandra, Macasoi Ioana Gabriela, Marti Daniela, Mioc Marius, Soica Codruta, Coricovac Dorina, Horhat Delia, Poenaru Marioara, Dehelean Cristina
Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 1, 300041 Timisoara, Romania.
Faculty of Pharmacy, "Victor Babeș" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania.
Antibiotics (Basel). 2021 Apr 7;10(4):401. doi: 10.3390/antibiotics10040401.
Antibiotics are considered as a cornerstone of modern medicine and their discovery offers the resolution to the infectious diseases problem. However, the excessive use of antibiotics worldwide has generated a critical public health issue and the bacterial resistance correlated with antibiotics inefficiency is still unsolved. Finding novel therapeutic approaches to overcome bacterial resistance is imperative, and natural compounds with antibacterial effects could be considered a promising option. The role played by antibiotics in tumorigenesis and their interrelation with the microbiota are still debatable and are far from being elucidated. Thus, the present manuscript offers a global perspective on antibiotics in terms of evolution from a historical perspective with an emphasis on the main classes of antibiotics and their adverse effects. It also highlights the connection between antibiotics and microbiota, focusing on the dual role played by antibiotics in tumorigenesis. In addition, using the natural compounds with antibacterial properties as potential alternatives for the classical antibiotic therapy is discussed.
抗生素被视为现代医学的基石，它们的发现为解决传染病问题提供了方法。然而，全球范围内抗生素的过度使用引发了一个严重的公共卫生问题，与抗生素疗效不佳相关的细菌耐药性问题仍然没有得到解决。寻找克服细菌耐药性的新治疗方法势在必行，具有抗菌作用的天然化合物可被视为一个有前景的选择。抗生素在肿瘤发生中的作用及其与微生物群的相互关系仍存在争议，远未得到阐明。因此，本手稿从历史角度对抗生素的演变提供了一个全面的视角，重点介绍了主要抗生素类别及其不良反应。它还强调了抗生素与微生物群之间的联系，重点关注抗生素在肿瘤发生中所起的双重作用。此外，还讨论了使用具有抗菌特性的天然化合物作为传统抗生素治疗的潜在替代品。
