Pandey Ragini, Gupta Puneet
Department of Pharmacy, Amity Institute of Pharmacy, Amity University, Uttar Pradesh, Sector 125, Noida, 201313, India.
Curr Drug Res Rev. 2025;17(2):191-205. doi: 10.2174/0125899775267934240308065823.
The global health of individuals is severely threatened by drug-resistant microorganisms. Existing antibiotics available in the market, such as penicillin, cephalosporins, new β- lactams, aminoglycosides, macrolides, lincomycin, and quinolones, are losing their effectiveness due to overuse and inappropriate prescribing, among other factors. This situation underscores the urgent need to develop new antimicrobial agents. In response to this challenge, attention has been directed towards natural products derived from plants, which have been utilized for their medicinal benefits over an extended period. Various studies have demonstrated that plant-based natural products exhibit antibacterial action against multidrug-resistant (MDR) bacteria, making them potential candidates for the development of novel antimicrobial medicines. Plants belonging to classes, such as alkaloids, organosulfur compounds, terpenoids, coumarin, and polyphenols have been found to possess antimicrobial properties. This paper reviews the antimicrobial activity of plant-based natural products, whether used alone or in combination with conventional antibiotics. Additionally, the paper explores their mechanisms against drugresistant bacteria, the potential development of resistance against them, their current role in medicine, and their future perspectives.
耐药微生物对全球个人健康构成严重威胁。市场上现有的抗生素，如青霉素、头孢菌素、新型β-内酰胺类、氨基糖苷类、大环内酯类、林可霉素和喹诺酮类，由于过度使用和不适当的处方等因素，正在失去其有效性。这种情况凸显了开发新型抗菌药物的迫切需求。为应对这一挑战，人们将注意力转向了源自植物的天然产物，长期以来这些天然产物因其药用价值而被利用。各种研究表明，基于植物的天然产物对多重耐药（MDR）细菌具有抗菌作用，使其成为开发新型抗菌药物的潜在候选物。已发现属于生物碱、有机硫化合物、萜类、香豆素和多酚等类别的植物具有抗菌特性。本文综述了基于植物的天然产物单独使用或与传统抗生素联合使用时的抗菌活性。此外，本文还探讨了它们对抗耐药细菌的作用机制、对它们产生耐药性的潜在发展、它们目前在医学中的作用以及它们的未来前景。
