Experimental Pharmacotherapy, Walther-Straub-Institute of Pharmacology and Toxicology, Member of the German Center for Lung Research (DZL), LMU-Munich, 80336 Munich, Germany.
Cells. 2021 Apr 6;10(4):822. doi: 10.3390/cells10040822.
Members of the transient receptor potential (TRP) superfamily are broadly expressed in our body and contribute to multiple cellular functions. Most interestingly, the fourth member of the vanilloid family of TRP channels (TRPV4) serves different partially antagonistic functions in the respiratory system. This review highlights the role of TRPV4 channels in lung fibroblasts, the lung endothelium, as well as the alveolar and bronchial epithelium, during physiological and pathophysiological mechanisms. Data available from animal models and human tissues confirm the importance of this ion channel in cellular signal transduction complexes with Ca ions as a second messenger. Moreover, TRPV4 is an excellent therapeutic target with numerous specific compounds regulating its activity in diseases, like asthma, lung fibrosis, edema, and infections.
瞬时受体电位（TRP）超家族成员在我们的体内广泛表达，参与多种细胞功能。最有趣的是，香草素家族的 TRP 通道（TRPV4）的第四个成员在呼吸系统中发挥不同的部分拮抗功能。本综述强调了 TRPV4 通道在肺成纤维细胞、肺内皮细胞以及肺泡和支气管上皮细胞中的作用，这些作用涉及生理和病理生理机制。来自动物模型和人体组织的数据证实了该离子通道在细胞信号转导复合物中的重要性，其中 Ca 离子作为第二信使。此外，TRPV4 是一个极好的治疗靶点，有许多特定的化合物可以调节其在哮喘、肺纤维化、水肿和感染等疾病中的活性。
