Park Sohee, Oh Minyoung, Kim Jae Seung, Lee Jae-Hong, Yoon Young Wook, Roh Jee-Hoon
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Brain Sci. 2021 Apr 6;11(4):465. doi: 10.3390/brainsci11040465.
The recent advance of positron emission tomography (PET) tracers as biomarkers in Alzheimer's disease (AD) provides more insight into pathophysiology, preclinical diagnosis, and further therapeutic strategies. However, synergistic processes or interactions between amyloid and tau deposits are still poorly understood. To better understand their relationship in focal brain changes with clinical phenotypes, we focused on region-specific or atypical AD characterized by focal clinical presentations: Posterior cortical atrophy (PCA) and logopenic variant of primary progressive aphasia (lpvPPA). We compared three different PET images with F-THK-5351 (tau), F-Florbetaben (amyloid beta, Aβ), and F-Fluorodeoxyglucose (glucose metabolism) to investigate potential interactions among pathologies and clinical findings. Whereas the amyloid accumulations were widespread throughout the neocortex, tau retentions and glucose hypometabolism showed focal changes corresponding to the clinical features. The distinctly localized patterns were more prominent in tau PET imaging. These findings suggest that tau pathology correlates more closely to the clinical symptoms and the neurodegenerative processes than Aβ pathology in AD.
正电子发射断层扫描（PET）示踪剂作为阿尔茨海默病（AD）生物标志物的最新进展，为病理生理学、临床前诊断及进一步的治疗策略提供了更多见解。然而，淀粉样蛋白和tau蛋白沉积之间的协同过程或相互作用仍知之甚少。为了更好地理解它们在伴有临床表型的局灶性脑改变中的关系，我们聚焦于以局灶性临床表现为特征的区域特异性或非典型AD：后皮质萎缩（PCA）和原发性进行性失语的logopenic变异型（lpvPPA）。我们比较了三种不同的PET图像，分别使用F-THK-5351（tau蛋白）、F-Florbetaben（淀粉样β蛋白，Aβ）和F-氟脱氧葡萄糖（葡萄糖代谢），以研究病变与临床发现之间的潜在相互作用。虽然淀粉样蛋白积累广泛分布于整个新皮质，但tau蛋白滞留和葡萄糖低代谢显示出与临床特征相对应的局灶性改变。这种明显的局部化模式在tau蛋白PET成像中更为突出。这些发现表明，在AD中，tau蛋白病变比Aβ蛋白病变与临床症状及神经退行性过程的相关性更强。
