Shinn Lindsey J, Lagalwar Sarita
Skidmore College Neuroscience Program, Saratoga Springs, NY 12866, USA.
Antioxidants (Basel). 2021 Apr 8;10(4):573. doi: 10.3390/antiox10040573.
Growing evidence from neurodegenerative disease research supports an early pathogenic role for mitochondrial dysfunction in affected neurons that precedes morphological and functional deficits. The resulting oxidative stress and respiratory malfunction contribute to neuronal toxicity and may enhance the vulnerability of neurons to continued assault by aggregation-prone proteins. Consequently, targeting mitochondria with antioxidant therapy may be a non-invasive, inexpensive, and viable means of strengthening neuronal health and slowing disease progression, thereby extending quality of life. We review the preclinical and clinical findings available to date of the natural bioactive phenol resveratrol and two synthetic mitochondrial-targeted antioxidants, MitoQ and SkQ.
神经退行性疾病研究中越来越多的证据支持线粒体功能障碍在受影响神经元中发挥早期致病作用，这一作用先于形态和功能缺陷出现。由此产生的氧化应激和呼吸功能障碍会导致神经元毒性，并可能增强神经元对易聚集蛋白持续攻击的易感性。因此，用抗氧化疗法靶向线粒体可能是一种非侵入性、低成本且可行的方法，可增强神经元健康并减缓疾病进展，从而延长生活质量。我们综述了天然生物活性酚白藜芦醇以及两种合成的线粒体靶向抗氧化剂MitoQ和SkQ目前的临床前和临床研究结果。
