Ramadan Mohammad Said, Russo Vincenzo, Nigro Gerardo, Durante-Mangoni Emanuele, Zampino Rosa
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Department of Translational Medical Sciences, AORN Ospedali dei Colli-Monaldi Hospital, 80131 Naples, Italy.
J Clin Med. 2021 Apr 8;10(8):1569. doi: 10.3390/jcm10081569.
The liver-heart axis is a growing field of interest owing to rising evidence of complex bidirectional interplay between the two organs. Recent data suggest non-alcoholic fatty liver disease (NAFLD) has a significant, independent association with a wide spectrum of structural and functional cardiac diseases, and seems to worsen cardiovascular disease (CVD) prognosis. Conversely, the effect of cardiac disease on NAFLD is not well studied and data are mostly limited to cardiogenic liver disease. We believe it is important to further investigate the heart-liver relationship because of the tremendous global health and economic burden the two diseases pose, and the impact of such investigations on clinical decision making and management guidelines for both diseases. In this review, we summarize the current knowledge on NAFLD diagnosis, its systemic manifestations, and associations with CVD. More specifically, we review the pathophysiological mechanisms that govern the interplay between NAFLD and CVD and evaluate the relationship between different CVD treatments and NAFLD progression.
由于越来越多的证据表明肝脏和心脏之间存在复杂的双向相互作用，肝心轴成为一个日益受到关注的领域。最近的数据表明，非酒精性脂肪性肝病（NAFLD）与多种结构和功能性心脏病存在显著的独立关联，并且似乎会恶化心血管疾病（CVD）的预后。相反，心脏病对NAFLD的影响尚未得到充分研究，数据大多局限于心源性肝病。鉴于这两种疾病给全球健康和经济带来的巨大负担，以及此类研究对这两种疾病的临床决策和管理指南的影响，我们认为进一步研究心-肝关系非常重要。在这篇综述中，我们总结了目前关于NAFLD诊断、其全身表现以及与CVD关联的知识。更具体地说，我们回顾了支配NAFLD与CVD之间相互作用的病理生理机制，并评估了不同CVD治疗方法与NAFLD进展之间的关系。
