Tiozzo Eduard, Rodriguez Allan, Konefal Janet, Farkas Gary J, Maher Jennifer L, Lewis John E
Department of Physical Medicine and Rehabilitation, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Int J Environ Res Public Health. 2021 Apr 8;18(8):3926. doi: 10.3390/ijerph18083926.
The risk of developing Type 2 Diabetes Mellitus in people living with HIV (PLWH) can be four times greater and can occur at an earlier age and even without the presence of obesity compared to those without HIV. Therefore, the purpose of this analytical cross-sectional study was to determine the relationship between HIV duration and glucose metabolism among PLWH. Eighty-two PLWH were categorized into shorter (≤15 years) or longer HIV duration (≥16 years) and then compared for differences in demographics, physical and clinical characteristics, biomarkers, and dietary intake. Compared to those with shorter HIV duration ( = 34), those with longer HIV duration ( = 48) were on average older ( = 0.02), reported lower consumption of alcohol ( = 0.05), had higher levels of homeostasis model assessment of insulin resistance (HOMA-IR, = 0.02), were also more likely to be a woman ( = 0.06), and have higher levels of fasting insulin ( = 0.06). When adjusted for age and body weight, the levels of HOMA-IR and fasting insulin were higher ( = 0.02 and = 0.04) with longer compared to shorter HIV duration, respectively. Longer exposure to HIV infection is associated with impaired insulin sensitivity. Continuing research aimed at the long-term effects of HIV infection and (antiretroviral therapy) is required.
与未感染艾滋病毒的人相比，艾滋病毒感染者（PLWH）患2型糖尿病的风险可能高出四倍，且可能在更早的年龄出现，甚至在没有肥胖的情况下也会发生。因此，这项分析性横断面研究的目的是确定艾滋病毒感染者中艾滋病毒感染持续时间与葡萄糖代谢之间的关系。82名艾滋病毒感染者被分为艾滋病毒感染持续时间较短（≤15年）或较长（≥16年）两组，然后比较他们在人口统计学、身体和临床特征、生物标志物以及饮食摄入方面的差异。与艾滋病毒感染持续时间较短的人（n = 34）相比，艾滋病毒感染持续时间较长的人（n = 48）平均年龄更大（P = 0.02），报告的酒精消费量更低（P = 0.05），胰岛素抵抗的稳态模型评估水平（HOMA-IR，P = 0.02）更高，也更有可能是女性（P = 0.06），并且空腹胰岛素水平更高（P = 0.06）。在调整年龄和体重后，艾滋病毒感染持续时间较长的人HOMA-IR和空腹胰岛素水平分别更高（P = 0.02和P = 0.04）。长期感染艾滋病毒与胰岛素敏感性受损有关。需要继续开展针对艾滋病毒感染和（抗逆转录病毒疗法）长期影响的研究。
