Special Care and Gerodontology Unit, IMIB-Arrixaca, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, 30008 Murcia, Spain.
Department of Integral Pediatric Dentistry, University of Murcia, 30008 Murcia, Spain.
Int J Environ Res Public Health. 2021 Apr 8;18(8):3936. doi: 10.3390/ijerph18083936.
Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague-Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation ( = 0.124). Significant differences were found in reparative dentin formation between the treatment groups ( = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges.
生物陶瓷材料具有理想的生物学特性，其特点为无反应性和骨诱导性。它们在活髓治疗中的应用得到了扩展。本研究旨在评估和比较β-磷酸三钙（β-TCP）、羟基磷灰石（HA）和胶原（C）支架与矿化三氧化物凝聚体（MTA）对大鼠磨牙活髓的影响。32 颗 Sprague-Dawley 大鼠磨牙进行直接盖髓术，分别用β-TCP/HA/C（n = 16）和 MTA（n = 16）处理。30 天后，对实验组样本进行以下参数评估：牙髓炎症和活力程度、修复性牙本质的存在、成牙本质细胞层的均匀性和牙髓纤维化的存在。在炎症程度方面，HA/β-TCP/C 和 MTA 之间无统计学差异（ = 0.124）。两组治疗组之间在修复性牙本质形成方面存在显著差异（ = 0.0005）。在 MTA 处理组中观察到牙本质桥形成。HA/β-TCP/C 的局部作用与 MTA 相似，在不引起炎症和维持牙髓活力方面，尽管两种材料在牙本质桥形成方面存在显著差异。
