Fan Jingzhi, Abedi-Dorcheh Keyvan, Sadat Vaziri Asma, Kazemi-Aghdam Fereshteh, Rafieyan Saeed, Sohrabinejad Masoume, Ghorbani Mina, Rastegar Adib Fatemeh, Ghasemi Zahra, Klavins Kristaps, Jahed Vahid
Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka St 3, LV-1007 Riga, Latvia.
Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Pulka St 3, LV-1007 Riga, Latvia.
Polymers (Basel). 2022 May 20;14(10):2097. doi: 10.3390/polym14102097.
The musculoskeletal (MS) system consists of bone, cartilage, tendon, ligament, and skeletal muscle, which forms the basic framework of the human body. This system plays a vital role in appropriate body functions, including movement, the protection of internal organs, support, hematopoiesis, and postural stability. Therefore, it is understandable that the damage or loss of MS tissues significantly reduces the quality of life and limits mobility. Tissue engineering and its applications in the healthcare industry have been rapidly growing over the past few decades. Tissue engineering has made significant contributions toward developing new therapeutic strategies for the treatment of MS defects and relevant disease. Among various biomaterials used for tissue engineering, natural polymers offer superior properties that promote optimal cell interaction and desired biological function. Natural polymers have similarity with the native ECM, including enzymatic degradation, bio-resorb and non-toxic degradation products, ability to conjugate with various agents, and high chemical versatility, biocompatibility, and bioactivity that promote optimal cell interaction and desired biological functions. This review summarizes recent advances in applying natural-based scaffolds for musculoskeletal tissue engineering.
肌肉骨骼（MS）系统由骨骼、软骨、肌腱、韧带和骨骼肌组成，它们构成了人体的基本框架。该系统在身体的正常功能中起着至关重要的作用，包括运动、保护内部器官、支撑、造血和姿势稳定。因此，MS组织的损伤或丧失会显著降低生活质量并限制活动能力，这是可以理解的。在过去几十年中，组织工程及其在医疗行业中的应用一直在迅速发展。组织工程为开发治疗MS缺陷和相关疾病的新治疗策略做出了重大贡献。在用于组织工程的各种生物材料中，天然聚合物具有促进最佳细胞相互作用和所需生物学功能的卓越特性。天然聚合物与天然细胞外基质（ECM）具有相似性，包括酶促降解、生物可吸收和无毒降解产物、与各种试剂共轭的能力，以及促进最佳细胞相互作用和所需生物学功能的高化学多功能性、生物相容性和生物活性。本综述总结了应用天然基支架进行肌肉骨骼组织工程的最新进展。
