Kimm Melanie A, Klenk Christopher, Alunni-Fabbroni Marianna, Kästle Sophia, Stechele Matthias, Ricke Jens, Eisenblätter Michel, Wildgruber Moritz
Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.
Department of Diagnostic and Interventional Radiology, Freiburg University Hospital, 79106 Freiburg, Germany.
Biomedicines. 2021 Apr 2;9(4):374. doi: 10.3390/biomedicines9040374.
Tumor-associated macrophages (TAMs) represent the largest group of leukocytes within the tumor microenvironment (TME) of solid tumors and orchestrate the composition of anti- as well as pro-tumorigenic factors. This makes TAMs an excellent target for novel cancer therapies. The plasticity of TAMs resulting in varying membrane receptors and expression of intracellular proteins allow the specific characterization of different subsets of TAMs. Those markers similarly allow tracking of TAMs by different means of molecular imaging. This review aims to provides an overview of the origin of tumor-associated macrophages, their polarization in different subtypes, and how characteristic markers of the subtypes can be used as targets for molecular imaging and theranostic approaches.
肿瘤相关巨噬细胞（TAM）是实体瘤肿瘤微环境（TME）中最大的白细胞群体，可协调抗肿瘤和促肿瘤发生因子的组成。这使得TAM成为新型癌症治疗的理想靶点。TAM的可塑性导致其膜受体和细胞内蛋白质表达各异，从而能够对不同亚群的TAM进行特异性表征。这些标志物同样有助于通过不同的分子成像手段追踪TAM。本综述旨在概述肿瘤相关巨噬细胞的起源、它们向不同亚型的极化过程，以及这些亚型的特征性标志物如何用作分子成像和诊疗方法的靶点。
