一名驻韩美军丛林斑疹伤寒患者伴有焦痂的临床病例及基于多重PCR的下一代测序基因鉴定
A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Using Multiplex PCR-Based Next-Generation Sequencing.
作者信息
Cho Seungchan, Allison Jon C, Park Kkothanahreum, No Jin Sun, Lee Seung-Ho, Park Kyungmin, Kim Jongwoo, Klein Terry A, Kim Heung-Chul, Kim Won-Keun, Song Jin-Won
机构信息
Department of Microbiology, College of Medicine, Korea University, Seoul 02841, Korea.
Force Health Protection and Preventive Medicine, MEDDAC-Korea, 65th Medical Brigade, Unit 15281, APO AP 96251-5281, USA.
出版信息
Pathogens. 2021 Apr 2;10(4):424. doi: 10.3390/pathogens10040424.
An epidemiological investigation was conducted for a scrub typhus case reported in a U.S. Forces Korea military patient in the Republic of Korea in November 2018. The patient had a fever, maculopapular rash, and an eschar. The full-length sequence of 56-kDa type-specific antigen (TSA) gene was obtained from eschar tissue by multiplex PCR-based Next Generation Sequencing for genetic identification. Based on the 56-kDa TSA gene, the aligned most closely with the Boryong strain.
对2018年11月在大韩民国一名驻韩美军患者中报告的一例恙虫病病例进行了流行病学调查。该患者有发热、斑丘疹和焦痂。通过基于多重PCR的下一代测序从焦痂组织中获得56-kDa型特异性抗原（TSA）基因的全长序列用于基因鉴定。基于56-kDa TSA基因，其与保宁菌株的亲缘关系最为密切。
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