Cuccia Francesco, Corradini Stefanie, Mazzola Rosario, Spiazzi Luigi, Rigo Michele, Bonù Marco Lorenzo, Ruggieri Ruggero, Buglione di Monale E Bastia Michela, Magrini Stefano Maria, Alongi Filippo
Advanced Radiation Oncology Department, Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Italy.
Department of Radiation Oncology, University Hospital Munich Campus Grosshadern, 81377 Munchen, Germany.
Cancers (Basel). 2021 Apr 9;13(8):1791. doi: 10.3390/cancers13081791.
In this review we summarize the currently available evidence about the role of hybrid machines for MR-guided radiotherapy for prostate stereotactic body radiotherapy. Given the novelty of this technology, to date few data are accessible, but they all report very promising results in terms of tolerability and preliminary clinical outcomes. Most of the studies highlight the favorable impact of on-board magnetic resonance imaging as a means to improve target and organs at risk identification with a consequent advantage in terms of dosimetric results, which is expected to relate to a more favorable toxicity pattern. Still, the longer treatment time per session may potentially affect the patient's compliance to the treatment, although first quality of life assessment studies have reported substantial tolerability and no major impact on quality of life. Finally, in this review we hypothesize some future scenarios of further investigation, based on the possibility to explore the superior anatomy visualization and the role of daily adapted treatments provided by hybrid MR-Linacs.
在本综述中，我们总结了关于混合机器在磁共振引导下的前列腺立体定向体部放射治疗中的作用的现有证据。鉴于这项技术的新颖性，目前可获取的数据很少，但所有数据均报告了在耐受性和初步临床结果方面非常有前景的结果。大多数研究强调了机载磁共振成像作为一种改善靶区和危及器官识别的手段所产生的有利影响，进而在剂量学结果方面具有优势，这有望带来更有利的毒性模式。尽管首批生活质量评估研究报告了较高的耐受性且对生活质量没有重大影响，但每次治疗时间较长仍可能会影响患者对治疗的依从性。最后，在本综述中，基于探索混合磁共振直线加速器提供的卓越解剖结构可视化以及每日适应性治疗的作用的可能性，我们推测了一些未来进一步研究的情景。
