Kang Sung-Goo, Hwang Hyun Jee, Kim Youngwoo, Lee Junseak, Oh Jung Hwan, Kim Jinsu, Lim Chul-Hyun, Youn Seung Bae, Jung Sung Hoon
Department of Family Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea.
Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Korea.
J Clin Med. 2021 Apr 9;10(8):1588. doi: 10.3390/jcm10081588.
Gastroesophageal reflux disease (GERD) is a chronic, recurrent disease. Reflux esophagitis can interfere with sleep via acid reflux, which can cause daytime sleepiness or fatigue. However, little is known about the association between reflux esophagitis and fatigue.
We evaluated the association between fatigue and reflux esophagitis in subjects seen at health check-ups.
Consecutive patients who were scheduled for screening endoscopies were enrolled prospectively at the Comprehensive Medical Examination Center of St. Vincent Hospital and Eunpyeong St. Mary's Hospital, Korea. Three validated questionnaires were used to assess fatigue, daytime hypersomnolence, anxiety, and depression: the Multidimensional Fatigue Inventory-Korean version (MFI-K), Epworth Sleepiness Scale (ESS), and Hospital Anxiety and Depression Scale (HADS).
We investigated 497 consecutive eligible subjects. The reflux esophagitis and symptomatic GERD groups comprised 103 (20.7%) and 92 (18.5%) subjects, respectively. The MFI-K total, ESS, HADS-anxiety, and HADS-depression scores did not differ between the esophagitis and non-esophagitis groups (50.0 ± 11.5 vs. 49.7 ± 10.9, = 0.661; 6.2 ± 2.8 vs. 6.1 ± 3.1, = 0.987; 5.8 ± 3.1 vs. 5.2 ± 3.2, = 0.060; 6.2 ± 3.6 vs. 6.0 ± 3.3, = 0.561). However, the MFI-K total, ESS, HADS-anxiety, and HADS-depression scores were higher in the symptomatic group than in the non-symptomatic group (54.7 ± 12.7 vs. 48.6 ± 10.3, < 0.001; 7.1 ± 3.5 vs. 5.9 ± 2.9, = 0.002; 6.4 ± 3.3 vs. 5.1 ± 3.1, < 0.001; 7.5 ± 4.0 vs. 5.7 ± 3.1, < 0.001). Multiple regression analysis showed that the MFI-K total was correlated with GERD symptoms ( = 0.021), women ( = 0.001), anxiety ( < 0.001), and depression ( < 0.001).
There was no statistically significant association in which reflux esophagitis could cause daytime sleepiness, fatigue, anxiety, or depression. However, fatigue was associated with GERD symptoms, women, anxiety, and depression. Further studies should clarify the association between fatigue and reflux esophagitis.
胃食管反流病（GERD）是一种慢性复发性疾病。反流性食管炎可通过胃酸反流干扰睡眠，进而导致日间嗜睡或疲劳。然而，关于反流性食管炎与疲劳之间的关联知之甚少。
我们评估了在健康体检中接受检查的受试者疲劳与反流性食管炎之间的关联。
在韩国圣文森特医院和恩平圣母医院综合体检中心前瞻性纳入计划进行筛查性内镜检查的连续患者。使用三份经过验证的问卷来评估疲劳、日间过度嗜睡、焦虑和抑郁：多维疲劳量表 - 韩语版（MFI - K）、爱泼华嗜睡量表（ESS）和医院焦虑抑郁量表（HADS）。
我们调查了497名连续符合条件的受试者。反流性食管炎组和有症状的GERD组分别包括103名（20.7%）和92名（18.5%）受试者。食管炎组和非食管炎组之间的MFI - K总分、ESS、HADS - 焦虑和HADS - 抑郁评分无差异（50.0±11.5对49.7±10.9，P = 0.661；6.2±2.8对6.1±3.1，P = 0.987；5.8±3.1对5.2±3.2，P = 0.060；6.2±3.6对6.0±3.3，P = 0.561）。然而，有症状组的MFI - K总分、ESS、HADS - 焦虑和HADS - 抑郁评分高于无症状组（54.7±12.7对48.6±10.3，P < 0.001；7.1±3.5对5.9±2.9，P = 0.002；6.4±3.3对5.1±3.1，P < 0.001；7.5±4.0对5.7±3.1，P < 0.001）。多元回归分析显示，MFI - K总分与GERD症状（P = 0.021）、女性（P = 0.001）、焦虑（P < 0.001）和抑郁（P < 0.001）相关。
反流性食管炎与日间嗜睡、疲劳、焦虑或抑郁之间不存在统计学上的显著关联。然而，疲劳与GERD症状、女性、焦虑和抑郁相关。进一步的研究应阐明疲劳与反流性食管炎之间的关联。
