Department of Internal Medicine, Ewha Womans University School of Medicine, 911-1 Mock-dong, Yangchun-ku, Seoul, 158-710, Korea.
Dig Dis Sci. 2013 Feb;58(2):471-7. doi: 10.1007/s10620-012-2377-z. Epub 2012 Sep 22.
The prevalence of reflux esophagitis is increasing in Korea. Reflux esophagitis aggravates the stress and fatigue level of daily life, but less is known about the association with stress and fatigue, which could be bi-directional.
To evaluate the impact of reflux esophagitis on stress and fatigue and to compare the stress level of people with reflux esophagitis with that of controls with peptic ulcer disease and healthy controls.
Among a total of 9,033 subjects who underwent a comprehensive medical check-up including upper endoscopy, 6,834 subjects (75.7 %) were enrolled. Stress and fatigue scores were measured by a validated Korean version of the Brief Encounter Psychosocial Instrument and the Fatigue Severity Scale.
Among 6,834 subjects, 13.2 % were in the high-stress group, and reflux esophagitis was found in 6.0 %. After adjustment for confounders, reflux esophagitis was significantly associated with high stress (odds ratio 1.94, 95 % confidence interval 1.25-3.02). Subjects with reflux esophagitis had significantly higher BEPSI-K scores compared with healthy controls (p = 0.027); and however, there was no significant difference in BEPSI-K scores between reflux esophagitis group and peptic ulcer disease controls. Fatigue severity scale was highly correlated with BEPSI-K (p < 0.001); however, there was no significant difference in fatigue severity scale level between the reflux esophagitis group and controls. The severity of reflux esophagitis was significantly correlated with BEPSI-K score (p = 0.008).
Reflux esophagitis is significantly associated with psychosocial stress, and the severity of reflux esophagitis correlates with the degree of stress.
反流性食管炎在韩国的患病率正在增加。反流性食管炎会加重日常生活的压力和疲劳程度，但人们对其与压力和疲劳的关系知之甚少，而这种关系可能是双向的。
评估反流性食管炎对压力和疲劳的影响，并比较反流性食管炎患者与消化性溃疡疾病对照组和健康对照组的压力水平。
在总共接受包括上内窥镜检查在内的综合体检的 9033 名受试者中，有 6834 名（75.7%）被纳入。使用经过验证的韩国版Brief Encounter Psychosocial Instrument 和 Fatigue Severity Scale 来测量压力和疲劳评分。
在 6834 名受试者中，有 13.2%处于高压力组，其中发现 6.0%患有反流性食管炎。在调整混杂因素后，反流性食管炎与高压力显著相关（优势比 1.94，95%置信区间 1.25-3.02）。与健康对照组相比，患有反流性食管炎的受试者的 BEPSI-K 评分显著更高（p=0.027）；然而，反流性食管炎组与消化性溃疡疾病对照组之间的 BEPSI-K 评分无显著差异。疲劳严重程度量表与 BEPSI-K 高度相关（p<0.001）；然而，反流性食管炎组与对照组之间的疲劳严重程度量表水平无显著差异。反流性食管炎的严重程度与 BEPSI-K 评分显著相关（p=0.008）。
反流性食管炎与社会心理压力显著相关，且反流性食管炎的严重程度与压力程度相关。
