Washino Satoshi, Ugata Yusuke, Saito Kimitoshi, Miyagawa Tomoaki
Department of Urology, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan.
Department of Cardiology, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan.
J Clin Med. 2021 Apr 9;10(8):1603. doi: 10.3390/jcm10081603.
The associations of nocturia with hypertension and anti-hypertensive agents (AHTs) remain to be validated.
This cross-sectional study examined whether blood pressure and/or frequently used classes of AHTs had consistent associations with nocturia.
A total of 418 male patients aged ≥ 40 years were retrospectively assessed in terms of the International Prostate Symptom Score (IPSS), prescription medications, and blood pressure. Nocturia was evaluated using item 7 of the IPSS, and two or more episodes of nocturia per night was considered to indicate clinically important nocturia.
Patients taking calcium channel blockers (CCBs), but not other AHTs, experienced more episodes of nocturia than patients not taking AHTs (1.77 ± 1.07, 1.90 ± 1.19, and 1.48 ± 0.98 in CCBs alone, CCBs + other AHTs, and other AHTs alone, vs. 1.35 ± 1.08 in not taking AHTs; = 0.014, < 0.0001, and = 0.91, respectively), whereas there was no significant difference in the number of nocturia episodes between patients with elevated and normal blood pressure. In multivariate analysis, CCB (odds ratio (OR) = 2.68, < 0.0001) and age (OR = 1.06, < 0.0001) were independently associated with clinically important nocturia.
CCB was associated with nocturia, while AHTs other than CCBs and elevated blood pressure were not.
夜尿症与高血压及抗高血压药物（AHTs）之间的关联仍有待验证。
这项横断面研究调查了血压和/或常用的AHTs类别与夜尿症之间是否存在一致的关联。
对418名年龄≥40岁的男性患者进行回顾性评估，内容包括国际前列腺症状评分（IPSS）、处方药和血压。使用IPSS的第7项评估夜尿症，每晚夜尿发作两次或更多次被认为表明存在具有临床意义的夜尿症。
服用钙通道阻滞剂（CCBs）的患者，而非服用其他AHTs的患者，比未服用AHTs的患者经历更多次夜尿发作（仅服用CCBs、CCBs + 其他AHTs、仅服用其他AHTs的患者分别为1.77 ± 1.07、1.90 ± 1.19和1.48 ± 0.98，未服用AHTs的患者为1.35 ± 1.08；P = 0.014、P < 0.0001和P = 0.91），而血压升高和正常的患者之间夜尿发作次数无显著差异。在多变量分析中，CCB（比值比（OR） = 2.68，P < 0.0001）和年龄（OR = 1.06，P < 0.0001）与具有临床意义的夜尿症独立相关。
CCB与夜尿症相关，而CCBs以外的AHTs和血压升高与夜尿症无关。
