Hsueh Fu-Chun, Wang Sheng-Yuan, Lin Wei-Hao, Lin Chuen-Fu, Tsai Chen-Yu, Huang Chin-Wen, Sun Ning, Chiou Ming-Tang, Lin Chao-Nan
Animal Disease Diagnostic Center, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
Vaccines (Basel). 2021 Apr 21;9(5):414. doi: 10.3390/vaccines9050414.
Porcine reproductive and respiratory syndrome (PRRS), which is caused by a highly transmissible pathogen called porcine reproductive and respiratory syndrome virus (PRRSV), has caused severe problems, including reproductive disorders in sows and respiratory symptoms in nursery pigs worldwide, since the early 1990s. However, currently available PRRSV vaccines do not supply complete immunity to confront the viral infection. Elicitation of PRRSV-specific neutralizing antibodies (NAbs) during the preinfectious period has been deemed to be a feasible strategy to modulate this virus, especially in farms where nursery pigs are seized with PRRSVs. A total of 180 piglets in a farrow-to-finish farm that had a natural outbreak of PRRS were distributed into three groups based on the different PRRSV NAbs levels in their dams. In the present study, piglets that received superior maternal-transferred NAbs showed delayed and relatively slight viral loads in serum and, on the whole, higher survival rates against wild PRRSV infections. A positive correlation of maternal NAbs between sows and their piglets was identified; moreover, high NAbs titers in piglets can last for at least 4 weeks. These results provide updated information to develop an appropriate immune strategy for breeding and for future PRRSV control under field conditions.
自20世纪90年代初以来，由一种名为猪繁殖与呼吸综合征病毒（PRRSV）的高传染性病原体引起的猪繁殖与呼吸综合征（PRRS），在全球范围内引发了严重问题，包括母猪的繁殖障碍和保育猪的呼吸道症状。然而，目前可用的PRRSV疫苗并不能提供完全的免疫力来对抗病毒感染。在感染前期激发PRRSV特异性中和抗体（NAbs）被认为是调控这种病毒的一种可行策略，尤其是在保育猪感染PRRSV的猪场。一个自繁自养猪场发生了PRRS自然疫情，根据母猪体内不同的PRRSV NAbs水平，将180头仔猪分为三组。在本研究中，接受了高水平母源传递NAbs的仔猪血清中的病毒载量出现延迟且相对较低，总体而言，对野生PRRSV感染的存活率更高。研究确定了母猪和仔猪之间母源NAbs的正相关性；此外，仔猪中的高NAbs滴度至少可以持续4周。这些结果为制定适当的免疫策略以进行育种以及在田间条件下未来控制PRRSV提供了最新信息。
