Boehringer Ingelheim Animal Health, Sant Cugat del Vallès, Barcelona, Spain.
Department of Physiology, Faculty of Veterinary Science, University of Murcia, Murcia, Spain.
BMC Vet Res. 2024 Oct 11;20(1):461. doi: 10.1186/s12917-024-04065-0.
Erysipelas still causes large economic losses to pig industry. Maternal immunity is critical to prevent erysipelas in young animals, thus, intensive vaccination protocols or practices focused on the improvement of the maternally derived immunity could provide substantial benefits. The present study evaluates potential changes in antibodies levels in sows and their offspring using two types of tests (commercial ELISA, Ingenasa or rSpaA415 ELISA) when two different vaccination programs (before farrowing or after farrowing) against Erysipelothrix rhusiopathiae were applied to sows from Iberian (A) or conventional Large White-Landrace (B) pig farms. The results showed a statistical correlation between titers found in sows and their one-week old piglets in both tests. The overall mean of (log) antibody titers in farm B measured by the commercial ELISA test was significantly higher in pre-farrowing vaccinated sows compared to the post-farrowing vaccine protocol (p = 0.0278). Additionally, using the rSpaA415 ELISA test, the overall mean of (log) antibody titers was significantly higher in pre-farrowing sows (p = 0.0056) compared to sows following post-farrowing vaccine protocol (p = 0.0003) or non- vaccinated sows. None of the above-mentioned differences were found in farm A. The overall mean of (log) antibody titers in piglets from the pre-farrowing vaccination protocol was significantly higher than piglets from the post-farrowing vaccination protocol in farm A (p = 0.0059; rSpaA415 ELISA) and farm B (p = 0.0168 and p = 0.0098 for the commercial and rSpaA415 ELISA data, respectively). Additionally, higher proportion of piglets from pre-farrowing vaccinated sows remained seropositive during the post-weaning period (days 42 to 84) compared to piglets from non-vaccinated or post-farrowing vaccinated groups in both farms A and B.
类丹毒仍然给养猪业造成巨大的经济损失。母源抗体对于预防幼畜的类丹毒至关重要，因此，强化疫苗接种方案或专注于提高母源抗体的措施可以带来实质性的好处。本研究使用两种类型的检测方法（商业 ELISA、Ingenasa 或 rSpaA415 ELISA），评估了两种不同的疫苗接种方案（产前或产后）对伊比利亚（A）或传统长白-兰德瑞斯（B）猪群母猪及其后代的抗体水平的潜在变化。结果表明，两种检测方法均显示出母猪与其一周龄仔猪之间的滴度存在统计学相关性。在使用商业 ELISA 检测的 B 场中，与产后疫苗方案相比，产前免疫母猪的总平均（log）抗体滴度显著更高（p=0.0278）。此外，使用 rSpaA415 ELISA 检测，产前母猪的总平均（log）抗体滴度显著高于产后疫苗方案的母猪（p=0.0056）或未接种疫苗的母猪（p=0.0003）。在 A 场中未发现上述差异。A 场和 B 场中，产前疫苗方案的仔猪总平均（log）抗体滴度均显著高于产后疫苗方案的仔猪（p=0.0059；rSpaA415 ELISA）和（p=0.0168 和 p=0.0098，对于商业和 rSpaA415 ELISA 数据分别）。此外，与未接种疫苗或产后接种疫苗的母猪所产仔猪相比，产前接种疫苗的母猪所产仔猪在断奶后（第 42 至 84 天）保持血清阳性的比例更高。
