Kim Min-Jee, Bose Shambhunath, Shin Na-Rae, Park Seohyun, Kwon Ojin, Song Eun-Ji, Nam Young-Do, Koo Byung-Soo, Nam Dong-Hyun, Lee Jun-Hwan, Kim Hojun
Department of Rehabilitation Medicine of Korean Medicine, Dongguk University, Goyang 10326, Korea.
Division of Clinical Medicine, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.
J Pers Med. 2021 Apr 21;11(5):325. doi: 10.3390/jpm11050325.
Cheonwangbosim-dan (CWBSD) is a traditional Korean herb formula that has been widely prescribed for insomnia patients with a heart-yin deficiency (HYD) pattern. Several studies have reported that heart function and insomnia are interrelated, and few have explored associations between insomnia, oral microbiota, and tongue diagnosis. This study aimed to evaluate the effects of CWBSD on primary insomnia, tongue diagnosis, and oral microbiota. At baseline, 56 patients with primary insomnia were assigned to two groups, a HYD group and a non-HYD (NHYD) group and they took CWBSD for 6 weeks. During the study, Pittsburgh Sleep Quality Indices (PSQIs) and Insomnia Severity Indices (ISIs) decreased significantly in both groups. However, the PSQI reduction observed in the HYD group was greater than in the NHYD group and sleep times increased only in the HYD group. As sleep quality improved, the amount of tongue coating increased at the posterior tongue, where heart function appears. At baseline, the HYD and NHYD group had a specific oral microbiota ( at genus level), but no significant change was observed after taking CWBSD. Additionally, subjects were divided into two oral microbiota types ("orotypes"). The genera , , or were abundant in each orotype. The reduction in PSQI in orotype 1 during the 6-week treatment period was greater than in orotype 2. In conclusion, this study shows that CWBSD could be used to treat primary insomnia in patients with a HYD pattern as determined using tongue diagnosis and oral microbiota distributional patterns.
天王补心丹（CWBSD）是一种传统的韩国草药配方，已被广泛用于治疗心阴不足（HYD）型失眠患者。多项研究报告称心脏功能与失眠相互关联，而很少有研究探讨失眠、口腔微生物群和舌诊之间的关系。本研究旨在评估天王补心丹对原发性失眠、舌诊和口腔微生物群的影响。在基线时，56名原发性失眠患者被分为两组，即HYD组和非HYD（NHYD）组，他们服用天王补心丹6周。在研究期间，两组的匹兹堡睡眠质量指数（PSQIs）和失眠严重程度指数（ISIs）均显著下降。然而，HYD组观察到的PSQI降低幅度大于NHYD组，且仅HYD组的睡眠时间增加。随着睡眠质量的改善，在出现心脏功能的舌后部舌苔量增加。在基线时，HYD组和NHYD组有特定的口腔微生物群（属水平），但服用天王补心丹后未观察到显著变化。此外，受试者被分为两种口腔微生物群类型（“orotypes”）。每种orotype中 、 或 属丰富。在6周治疗期内，orotype 1中PSQI的降低幅度大于orotype 2。总之，本研究表明天王补心丹可用于治疗根据舌诊和口腔微生物群分布模式确定为HYD型的原发性失眠患者。
