MOE Key Laboratory of Bioinformatics and TCM-X center/Bioinformatics Division, BNRist/Department of Automation, Tsinghua University, Beijing, 100084, China.
Institute for Artificial Intelligence and Department of Computer Science and Technology, Tsinghua University, Beijing, 100084, China.
Protein Cell. 2019 Jul;10(7):496-509. doi: 10.1007/s13238-018-0596-6. Epub 2018 Nov 26.
The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progress. In this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrence and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis.
胃炎的发展与胃癌风险的增加有关。目前的侵袭性胃炎诊断方法并不适合监测病情进展。在这项基于 78 名胃炎患者和 50 名健康个体的研究中，我们观察到舌苔微生物群的变化与胃炎的发生和发展有关。我们鉴定出 21 种微生物物种，可用于区分胃炎患者和健康个体的舌苔微生物组。在胃炎患者中，微生物代谢多样化、抗生素生物合成和细菌趋化等途径被上调。我们发现，幽门弯曲菌的丰度与胃癌前级联反应有关。此外，在包含 38 名胃炎患者的验证队列中，我们在舌涂层和胃液中检测到幽门弯曲菌。这些观察结果为中医舌诊提供了生物学证据，并表明舌苔微生物组可能是一种潜在的非侵入性生物标志物，适用于长期监测胃炎。
