Clinical Investigation Center, Inserm CIC 1405, Bat 3C, University Hospital Clermont-Ferrand, F-63000 Clermont-Ferrand, France.
Rheumatology Department, University Hospital Clermont-Ferrand, F-63000 Clermont-Ferrand, France.
Nutrients. 2021 Apr 21;13(5):1397. doi: 10.3390/nu13051397.
Magnesium (Mg) is commonly used in clinical practice for acute and chronic pain and has been reported to reduce pain intensity and analgesics consumption in a number of studies. Results are, however, contested.
This review aims to investigate randomised clinical trials (RCTs) on the effectiveness of Mg treatment on pain and analgesics consumption in situations including post-operative pain, migraine, renal pain, chronic pain, neuropathic pain and fibromyalgia.
The literature search identified 81 RCTs ( = 5447 patients) on Mg treatment in pain (50 RCTs in post-operative pain, 18 RCTs in migraine, 5 RCTs in renal pain, 6 RCTs in chronic/neuropathic pain, 2 RCTs in fibromyalgia).
The level of evidence for the efficacy of Mg in reducing pain and analgesics consumption is globally modest and studies are not very numerous in chronic pain. A number of gaps have been identified in the literature that need to be addressed especially in methodology, rheumatic disease, and cancer. Additional clinical trials are needed to achieve a sufficient level of evidence and to better optimize the use of Mg for pain and pain comorbidities in order to improve the quality of life of patients who are in pain.
镁（Mg）在临床实践中常用于治疗急性和慢性疼痛，多项研究表明它能减轻疼痛强度和减少镇痛药的使用。然而，研究结果存在争议。
本综述旨在调查关于镁治疗对包括术后疼痛、偏头痛、肾痛、慢性疼痛、神经痛和纤维肌痛在内的各种疼痛情况的有效性的随机临床试验（RCT）。
文献检索确定了 81 项关于镁治疗疼痛的 RCT（=5447 名患者）（50 项 RCT 用于术后疼痛，18 项 RCT 用于偏头痛，5 项 RCT 用于肾痛，6 项 RCT 用于慢性/神经痛，2 项 RCT 用于纤维肌痛）。
镁在减轻疼痛和减少镇痛药使用方面的疗效的证据水平总体上较低，而且在慢性疼痛方面的研究并不多。文献中存在一些需要解决的空白，特别是在方法学、风湿性疾病和癌症方面。需要开展更多的临床试验以获得足够的证据水平，并更好地优化镁在疼痛和疼痛合并症中的使用，以提高疼痛患者的生活质量。
