• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

尼罗罗非鱼中短链脱氢酶/还原酶的鉴定、表达与进化()。

Identification, Expression and Evolution of Short-Chain Dehydrogenases/Reductases in Nile Tilapia ().

机构信息

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China.

Department of Biology, University of Maryland, College Park, MD 20742, USA.

出版信息

Int J Mol Sci. 2021 Apr 18;22(8):4201. doi: 10.3390/ijms22084201.

DOI:10.3390/ijms22084201
PMID:33919636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8073704/
Abstract

The short-chain dehydrogenases/reductases (SDR) superfamily is involved in multiple physiological processes. In this study, genome-wide identification and comprehensive analysis of superfamily were carried out in 29 animal species based on the latest genome databases. Overall, the number of genes in animals increased with whole genome duplication (WGD), suggesting the expansion of s during evolution, especially in 3R-WGD and polyploidization of teleosts. Phylogenetic analysis indicated that vertebrates SDRs were clustered into five categories: classical, extended, undefined, atypical, and complex. Moreover, tandem duplication of and was observed in teleosts analyzed. Additionally, tandem duplications of , , and were observed in all cichlids analyzed, and tandem duplication of was observed in tilapiines. Transcriptome analysis of adult fish revealed that 93 s were expressed in more than one tissue and 5 in one tissue only. Transcriptome analysis of gonads from different developmental stages showed that expression of 17 s were sexually dimorphic with 11 higher in ovary and 6 higher in testis. The sexually dimorphic expressions of these were confirmed by in situ hybridization () and qPCR, indicating their possible roles in steroidogenesis and gonadal differentiation. Taken together, the identification and the expression data obtained in this study contribute to a better understanding of SDR superfamily evolution and functions in teleosts.

摘要

短链脱氢酶/还原酶（SDR）超家族参与多种生理过程。本研究基于最新的基因组数据库，在 29 种动物物种中进行了超家族的全基因组鉴定和综合分析。总的来说，随着全基因组加倍（WGD），动物中的 SDR 基因数量增加，表明在进化过程中 s 的扩张，特别是在 3R-WGD 和硬骨鱼的多倍体化中。系统发育分析表明，脊椎动物 SDR 分为五类：经典、扩展、未定义、非典型和复杂。此外，还观察到硬骨鱼中 SDR 的串联重复。此外，在所有分析的慈鲷中观察到 SDR 的串联重复，在罗非鱼中观察到 SDR 的串联重复。成年鱼类的转录组分析显示，93 个 s 在一种以上组织中表达，5 个仅在一种组织中表达。来自不同发育阶段的性腺转录组分析显示，17 个 s 的表达具有性别二态性，11 个在卵巢中较高，6 个在睾丸中较高。这些 s 的性别二态性表达通过原位杂交（ISH）和 qPCR 得到证实，表明它们在类固醇生成和性腺分化中的可能作用。总之，本研究中的鉴定和表达数据有助于更好地理解 SDR 超家族在硬骨鱼中的进化和功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/79abe0b1e7e4/ijms-22-04201-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/40fb6c3b178a/ijms-22-04201-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/b3e8b5a3dc0a/ijms-22-04201-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/b491989b8035/ijms-22-04201-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/c37b2193f537/ijms-22-04201-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/71b6b2d9b142/ijms-22-04201-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/96f3bbd33c07/ijms-22-04201-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/d6995dfc6fc4/ijms-22-04201-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/79abe0b1e7e4/ijms-22-04201-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/40fb6c3b178a/ijms-22-04201-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/b3e8b5a3dc0a/ijms-22-04201-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/b491989b8035/ijms-22-04201-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/c37b2193f537/ijms-22-04201-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/71b6b2d9b142/ijms-22-04201-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/96f3bbd33c07/ijms-22-04201-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/d6995dfc6fc4/ijms-22-04201-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d6b/8073704/79abe0b1e7e4/ijms-22-04201-g008.jpg

相似文献

1
Identification, Expression and Evolution of Short-Chain Dehydrogenases/Reductases in Nile Tilapia ().尼罗罗非鱼中短链脱氢酶/还原酶的鉴定、表达与进化()。
Int J Mol Sci. 2021 Apr 18;22(8):4201. doi: 10.3390/ijms22084201.
2
Genome-wide identification, phylogeny, and gonadal expression of fox genes in Nile tilapia, Oreochromis niloticus.尼罗罗非鱼（Oreochromis niloticus）中fox基因的全基因组鉴定、系统发育及性腺表达
Fish Physiol Biochem. 2014 Aug;40(4):1239-52. doi: 10.1007/s10695-014-9919-6. Epub 2014 Feb 14.
3
Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus.尼罗罗非鱼（Oreochromis niloticus）核受体超家族的全基因组鉴定、进化及表达分析
Gene. 2015 Sep 10;569(1):141-52. doi: 10.1016/j.gene.2015.05.057. Epub 2015 May 27.
4
Genome-Wide Identification, Evolution and Expression of the Complete Set of Cytoplasmic Ribosomal Protein Genes in Nile Tilapia.尼罗罗非鱼细胞质核糖体蛋白基因家族的全基因组鉴定、进化和表达分析。
Int J Mol Sci. 2020 Feb 12;21(4):1230. doi: 10.3390/ijms21041230.
5
Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism.一种与骨代谢相关的鱼类短链脱氢酶/还原酶的鉴定。
Gene. 2018 Mar 1;645:137-145. doi: 10.1016/j.gene.2017.12.021. Epub 2017 Dec 14.
6
Genome-wide identification, evolution of histone lysine demethylases (KDM) genes and their expression during gonadal development in Nile tilapia.尼罗罗非鱼性腺发育过程中组蛋白赖氨酸去甲基酶（KDM）基因的全基因组鉴定、进化及其表达。
Comp Biochem Physiol B Biochem Mol Biol. 2022 Jan;257:110674. doi: 10.1016/j.cbpb.2021.110674. Epub 2021 Oct 6.
7
Genome-wide identification, evolution of ATF/CREB family and their expression in Nile tilapia.全基因组鉴定、ATF/CREB 家族的进化及其在尼罗罗非鱼中的表达。
Comp Biochem Physiol B Biochem Mol Biol. 2019 Nov;237:110324. doi: 10.1016/j.cbpb.2019.110324. Epub 2019 Aug 26.
8
Genome-Wide Identification and Characterization of Short-Chain Dehydrogenase/Reductase (SDR) Gene Family in .在. 中全基因组鉴定和短链脱氢酶/还原酶 (SDR) 基因家族的特征分析
Int J Mol Sci. 2021 Aug 31;22(17):9498. doi: 10.3390/ijms22179498.
9
Genome-wide identification, evolution of chromobox family genes and their expression in Nile tilapia.尼罗罗非鱼中染色体框家族基因的全基因组鉴定、进化及其表达
Comp Biochem Physiol B Biochem Mol Biol. 2017 Jan;203:25-34. doi: 10.1016/j.cbpb.2016.09.001. Epub 2016 Sep 7.
10
The plant short-chain dehydrogenase (SDR) superfamily: genome-wide inventory and diversification patterns.植物短链脱氢酶（SDR）超家族：全基因组的构成与多样化模式。
BMC Plant Biol. 2012 Nov 20;12:219. doi: 10.1186/1471-2229-12-219.

引用本文的文献

1
Bdh1l Gene Expression Is a Potential Molecular Factor in the Evolution of Carotenoid-Based Colour Diversity of Cichlid Fishes.Bdh1l基因表达是丽鱼科鱼类基于类胡萝卜素的颜色多样性进化中的一个潜在分子因素。
Mol Ecol. 2025 Sep;34(18):e70065. doi: 10.1111/mec.70065. Epub 2025 Aug 20.
2
Genome-wide identification of short-chain dehydrogenases/reductases genes and functional characterization of in melanin biosynthesis in .全基因组范围内短链脱氢酶/还原酶基因的鉴定及其在[物种名称]黑色素生物合成中的功能表征 。（你提供的原文中“in melanin biosynthesis in.”后面似乎缺少具体物种信息，这可能会影响译文的完整性和准确性，以上是根据现有内容尽量完整的翻译）
Front Microbiol. 2025 Jan 30;16:1532162. doi: 10.3389/fmicb.2025.1532162. eCollection 2025.
3

本文引用的文献

1
Deeply conserved synteny resolves early events in vertebrate evolution.深度保守的同线性解决了脊椎动物进化早期的事件。
Nat Ecol Evol. 2020 Jun;4(6):820-830. doi: 10.1038/s41559-020-1156-z. Epub 2020 Apr 20.
2
Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (): Genome-Wide Identification and Expression Analysis During Sex Reversal.斜带石斑鱼中的β-羟基类固醇脱氢酶基因（）：性别逆转过程中的全基因组鉴定与表达分析
Front Genet. 2020 Mar 4;11:161. doi: 10.3389/fgene.2020.00161. eCollection 2020.
3
Characteristics and sex dimorphism of 17β-hydroxysteroid dehydrogenase family genes in the olive flounder Paralichthys olivaceus.
Deciphering the structure of a multi-drug resistant Acinetobacter baumannii short-chain dehydrogenase reductase.
解析多药耐药鲍曼不动杆菌短链脱氢酶还原酶的结构。
PLoS One. 2024 Feb 23;19(2):e0297751. doi: 10.1371/journal.pone.0297751. eCollection 2024.
4
Bioinformatic analysis of short-chain dehydrogenase/reductase proteins in plant peroxisomes.植物过氧化物酶体中短链脱氢酶/还原酶蛋白的生物信息学分析
Front Plant Sci. 2023 Jun 9;14:1180647. doi: 10.3389/fpls.2023.1180647. eCollection 2023.
橄榄色牙鲆 17β-羟甾脱氢酶家族基因的特征和性别二态性。
J Steroid Biochem Mol Biol. 2020 May;199:105597. doi: 10.1016/j.jsbmb.2020.105597. Epub 2020 Jan 17.
4
Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C-steroids.人源脱氢酶/还原酶短链家族成员 11（DHRS11）和醛酮还原酶 1C 同工酶的比较：在 11-酮-C-甾体还原反应中的底物和反应特异性。
J Steroid Biochem Mol Biol. 2020 May;199:105586. doi: 10.1016/j.jsbmb.2020.105586. Epub 2020 Jan 8.
5
CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch.中枢神经系统髓鞘蛋白 36K 通过 Notch 调控少突胶质细胞分化。
Glia. 2020 Mar;68(3):509-527. doi: 10.1002/glia.23732. Epub 2019 Nov 8.
6
17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes.17B-羟甾类脱氢酶作为酰基辅酶 A 硫酯代谢酶。
Mol Cell Endocrinol. 2019 Jun 1;489:107-118. doi: 10.1016/j.mce.2018.11.012. Epub 2018 Nov 30.
7
Roles of estrogens in fish sexual plasticity and sex differentiation.雌激素在鱼类性可塑性和性别分化中的作用。
Gen Comp Endocrinol. 2019 Jun 1;277:9-16. doi: 10.1016/j.ygcen.2018.11.015. Epub 2018 Nov 27.
8
Identification and Evolution of TGF-β Signaling Pathway Members in Twenty-Four Animal Species and Expression in Tilapia.二十四种动物物种中 TGF-β 信号通路成员的鉴定与进化及罗非鱼中的表达
Int J Mol Sci. 2018 Apr 11;19(4):1154. doi: 10.3390/ijms19041154.
9
Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance.在骨骼肌中过度表达视黄醇脱氢酶（SRP35/DHRS7C）可激活 mTORC2，增强葡萄糖代谢和肌肉性能。
Sci Rep. 2018 Jan 12;8(1):636. doi: 10.1038/s41598-017-18844-3.
10
Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans.秀丽隐杆线虫脱氢酶/还原酶 SDR 家族成员 4（DHRS4）的晶体结构与催化特性研究。
FEBS J. 2018 Jan;285(2):275-293. doi: 10.1111/febs.14337. Epub 2017 Nov 28.