Department of Internal Medicine, San Cecilio University Hospital, Hospital Universitario San Cecilio, 18016 Granada, Spain.
Clinical Medicine and Public Health Doctoral Studies, University of Granada, 18010 Granada, Spain.
Int J Environ Res Public Health. 2021 Apr 10;18(8):3991. doi: 10.3390/ijerph18083991.
There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectiveness of different antalgic therapies (pharmacological and non-pharmacological) in the improvement of pain of these patients. To this end, this protocol has been written according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) and registered in PROSPERO (CRD42020135762). A systematic search will be carried out in four international databases: Medline (Via PubMed), Web of Science, Cochrane Library and SCOPUS, to select the randomized controlled clinical trials. The Risk of Bias Tool developed by Cochrane will be used to assess the risk of bias and the quality of the identified studies. A narrative synthesis will be used to describe and compare the studies, and after the data extraction, random effects model and a subgroup analyses will be performed according to the type of intervention, if possible. This protocol aims to generate a systematic review that compiles and synthesizes the best and most recent evidence on the treatment of pain derived from vertebral metastasis.
目前尚无系统评价确定现有的评估骨转移患者疼痛管理的药物和非药物干预措施的研究。为了填补这一文献空白，本系统评价和荟萃分析旨在评估不同镇痛疗法（药物和非药物）在改善这些患者疼痛方面的有效性。为此，本方案根据系统评价和荟萃分析报告的首选报告项目（PRISMA-P）编写，并在 PROSPERO（CRD42020135762）中进行了注册。将在四个国际数据库中进行系统搜索：Medline（通过 PubMed）、Web of Science、Cochrane Library 和 SCOPUS，以选择随机对照临床试验。将使用 Cochrane 制定的偏倚风险工具评估确定研究的偏倚风险和质量。将使用叙述性综合法描述和比较研究，并在提取数据后，根据干预类型（如果可能）进行随机效应模型和亚组分析。本方案旨在生成一份系统评价，综合和综合来自椎体转移的疼痛治疗的最佳和最新证据。
