Sirotkin Alexander V, Alwasel Saleh Hamad, Harrath Abdel Halim
Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 01 Nitra, Slovakia.
Department of Zoology, College of Science, King Saud University, Riyadh 12372, Saudi Arabia.
Pharmaceuticals (Basel). 2021 Apr 17;14(4):373. doi: 10.3390/ph14040373.
In this review, we explore the current literature on the influence of the plant isoflavone daidzein and its metabolite equol on animal and human physiological processes, with an emphasis on female reproduction including ovarian functions (the ovarian cycle; follicullo- and oogenesis), fundamental ovarian-cell functions (viability, proliferation, and apoptosis), the pituitary and ovarian endocrine regulators of these functions, and the possible intracellular mechanisms of daidzein action. Furthermore, we discuss the applicability of daidzein for the control of animal and human female reproductive processes, and how to make this application more efficient. The existing literature demonstrates the influence of daidzein and its metabolite equol on various nonreproductive and reproductive processes and their disorders. Daidzein and equol can both up- and downregulate the ovarian reception of gonadotropins, healthy and cancerous ovarian-cell proliferation, apoptosis, viability, ovarian growth, follicullo- and oogenesis, and follicular atresia. These effects could be mediated by daidzein and equol on hormone production and reception, reactive oxygen species, and intracellular regulators of proliferation and apoptosis. Both the stimulatory and the inhibitory effects of daidzein and equol could be useful for reproductive stimulation, the prevention and mitigation of cancer development, and the adverse effects of environmental stressors in reproductive biology and medicine.
在本综述中，我们探讨了关于植物异黄酮大豆苷元及其代谢产物雌马酚对动物和人类生理过程影响的现有文献，重点关注女性生殖，包括卵巢功能（卵巢周期、卵泡形成和卵子发生）、基本卵巢细胞功能（活力、增殖和凋亡）、这些功能的垂体和卵巢内分泌调节因子，以及大豆苷元作用的可能细胞内机制。此外，我们讨论了大豆苷元在控制动物和人类女性生殖过程中的适用性，以及如何提高这种应用的效率。现有文献表明大豆苷元及其代谢产物雌马酚对各种非生殖和生殖过程及其紊乱有影响。大豆苷元和雌马酚既能上调也能下调卵巢对促性腺激素的反应、健康和癌性卵巢细胞的增殖、凋亡、活力、卵巢生长、卵泡形成和卵子发生以及卵泡闭锁。这些作用可能是由大豆苷元和雌马酚对激素产生和反应、活性氧以及增殖和凋亡的细胞内调节因子介导的。大豆苷元和雌马酚的刺激和抑制作用对于生殖刺激、癌症发展的预防和缓解以及生殖生物学和医学中环境应激源的不利影响可能都有用。
