Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.
Department of Biotechnology, National College, Tribhuvan University, Kirtipur, Nepal.
Phytother Res. 2021 Mar;35(3):1298-1312. doi: 10.1002/ptr.6893. Epub 2020 Oct 9.
The whole world is entangled by the coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), people are dying in thousands each day, and without an actual medication, it seems not possible for the bringing this global health crisis to a stop. Natural products have been in constant use since ancient times and are proven by time to be effective. Crude extract or pure compounds isolated from medicinal plants and/or herbs such as Artemisia annua, Agastache rugosa, Astragalus membranaceus, Cassia alata, Ecklonia cava, Gymnema sylvestre, Glycyrrhizae uralensis, Houttuynia cordata, Lindera aggregata, Lycoris radiata, Mollugo cerviana, Polygonum multiflorum, Pyrrosia lingua, Saposhnikoviae divaricate, Tinospora cordifolia etc. have shown promising inhibitory effect against coronavirus. Several molecules, including acacetin, amentoflavone, allicin, blancoxanthone, curcumin, daidzein, diosmin, epigallocatechin-gallate, emodin, hesperidin, herbacetin, hirsutenone, iguesterin, jubanine G, kaempferol, lycorine, pectolinarin, phloroeckol, silvestrol, tanshinone I, taxifolin, rhoifolin, xanthoangelol E, zingerol etc. isolated from plants could also be potential drug candidates against COVID-19. Moreover, these could also show promising inhibitory effects against influenza-parainfluenza viruses, respiratory syncytial virus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have reported 93 antiviral drug candidates which could be a potential area of research in drug discovery.
全世界都被由严重急性呼吸系统综合征冠状病毒 2 引起的冠状病毒病（COVID-19）大流行所困扰，每天都有成千上万的人死亡，而且由于没有实际的药物，似乎不可能阻止这场全球健康危机。天然产物自古以来就一直在被使用，并且经过时间的验证是有效的。从药用植物和/或草药中分离出的粗提取物或纯化合物，如青蒿、藿香、黄芪、鸡冠花、裙带菜、匙羹藤、甘草、鱼腥草、山麦冬、乌药、石蒜、车前草、何首乌、虎杖、山豆根、穿心莲、延胡索、鬼臼毒素、桑白皮、没食子酸、大黄素、橙皮苷、表没食子儿茶素没食子酸酯、大黄素、橙皮苷、芹菜素、羟基喜树碱、毛喉鞘蕊花素、染料木素、柚皮苷、荭草苷、黄烷酮、异甘草素、桔皮素、紫檀芪、丹参酮 I、木犀草素、山柰酚、白杨素、虎杖苷等，都显示出对冠状病毒有很好的抑制作用。一些分子，包括芹菜素、山奈素、大蒜素、白鲜酮、姜黄素、大豆苷元、地奥司明、表没食子儿茶素没食子酸酯、大黄素、橙皮苷、芹菜素、羟基喜树碱、毛喉鞘蕊花素、染料木素、柚皮苷、荭草苷、黄烷酮、异甘草素、桔皮素、紫檀芪、丹参酮 I、木犀草素、山柰酚、白杨素、虎杖苷等，也可以成为对抗 COVID-19 的潜在药物候选物。此外，它们还可能对流感副流感病毒、呼吸道合胞病毒、严重急性呼吸系统综合征（SARS）和中东呼吸系统综合征冠状病毒（MERS-CoV）有很好的抑制作用。在这里，我们报告了 93 种抗病毒药物候选物，这可能是药物发现的一个潜在研究领域。
