Liu Jingkun, Zhao Fangfang, Xu Yanyang, Qiu Jing, Qian Yongzhong
Institute of Quality Standards & Testing Technology for Agro-Products, Key Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agricultural Sciences, Key Laboratory of Agri-Food Quality and Safety, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Analysis & Testing Center, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Foods. 2021 Apr 12;10(4):835. doi: 10.3390/foods10040835.
The low-level and long-term exposure of pesticides was found to induce metabolic syndrome to mice. Metabolic pathways and mechanisms were investigated by detecting gut flora with metabolites, host circulation, and their interrelations. Results showed that the abundances of flora species and their metabolism were altered, consequently leading to metabolic disorders. A correlation analysis between gut flora and their metabolic profiling further explained these changes and associations. The metabolic profiling of host circulation was also performed to characterize metabolic disorders. The associations of host circulation with gut flora were established via their significantly different metabolites. Alterations to the liver metabolism clarified potential pathways and mechanisms for the disorders. Metabolic disorders were evidently released by dietary and micro-ecological intervention, directly proving that gut flora comprise a vital medium in metabolic health risk caused by pesticide exposure. This work supplied theoretical bases and intervention approaches to body metabolic problems caused by pesticide exposure mediated by gut flora.
研究发现，低水平长期接触农药会诱导小鼠出现代谢综合征。通过检测肠道菌群及其代谢产物、宿主循环系统及其相互关系，对代谢途径和机制进行了研究。结果表明，菌群种类及其代谢丰度发生了改变，进而导致代谢紊乱。对肠道菌群及其代谢谱进行相关性分析，进一步解释了这些变化和关联。还对宿主循环系统的代谢谱进行了分析，以表征代谢紊乱。通过宿主循环系统与肠道菌群显著不同的代谢产物建立了它们之间的关联。肝脏代谢的改变阐明了这些紊乱的潜在途径和机制。饮食和微生态干预明显缓解了代谢紊乱，直接证明肠道菌群是农药暴露所致代谢健康风险中的重要媒介。这项工作为肠道菌群介导的农药暴露引起的身体代谢问题提供了理论依据和干预方法。
Zotero 插件
