交联剂类型对改性海藻酸钠/聚乙烯醇水凝胶性能的影响。

Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels.

机构信息

Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31-155 Cracow, Poland.

Department of Chemical Technology and Environmental Analytics, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska St., 31-155 Cracow, Poland.

出版信息

Molecules. 2021 Apr 19;26(8):2381. doi: 10.3390/molecules26082381.

Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, M = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% / calcium chloride solution. The compositions of SA/PVA/-based hydrogels contained a polymer of natural origin-sodium alginate (SA, 1.5% solution)-and a synthetic polymer-poly(vinyl alcohol) (PVA, M = 72,000 g/mol, 10% solution)-in the ratio 2:1, and different amounts of the aqueous extract of -5, 10, 15 or 20% (/). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

在这里，我们报告了不同交联方法（离子和化学）对含有天然来源活性物质的 SA/PVA 水凝胶的物理化学性质（溶胀能力和在模拟体液中的降解）、结构（FT-IR 光谱分析）和形态（SEM 分析）的影响的研究。首先，使用索氏提取仪制备了的水提物。接下来，通过使用聚乙二醇二丙烯酸酯（PEGDA，M = 700 g/mol）作为交联剂的化学交联方法以及在 5%/氯化钙溶液存在下的离子反应，获得了一系列改性的 SA/PVA 基水凝胶。SA/PVA/-基水凝胶的组成包含天然来源的聚合物-海藻酸钠（SA，1.5%溶液）和合成聚合物-聚乙烯醇（PVA，M = 72,000 g/mol，10%溶液），比例为 2:1，以及不同量的-水提物 -5、10、15 或 20% (/ )。此外，在 37°C 的磷酸盐缓冲盐水（PBS）中评估了松果菊苷从聚合物基质中的释放行为。结果表明，交联方法的类型对释放曲线有直接影响。因此，可以设计一种根据应用需要输送活性物质的系统。