Department of Microbiology and Immunology, Center for Infectious Diseases, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Cells. 2021 Apr 23;10(5):989. doi: 10.3390/cells10050989.
CD8 tissue-resident memory T (T) cells primarily reside in nonlymphoid tissues without recirculating and provide front-line protective immunity against infections and cancers. CD8 T cells can be generally divided into CD69 CD103 T cells (referred to as CD103 T cells) and CD69 CD103 T cells (referred to as CD103 T cells). TGF-β plays a critical role in the development and maintenance of CD103 CD8 T cells. In this review, we summarize the current understanding of tissue-specific activation of TGF-β mediated by integrins and how it contributes to CD103 CD8 T cell development and maintenance. Furthermore, we discuss the underlying mechanisms utilized by TGF-β to regulate the development and maintenance of CD103 CD8 T cells. Overall, this review highlights the importance of TGF-β in regulating this unique subset of memory CD8 T cells that may shed light on improving vaccine design to target this population.
CD8 组织驻留记忆 T（T）细胞主要存在于非淋巴组织中，不会再循环，为感染和癌症提供一线保护免疫。CD8 T 细胞通常可分为 CD69 CD103 T 细胞（简称 CD103 T 细胞）和 CD69 CD103 T 细胞（简称 CD103 T 细胞）。TGF-β 在 CD103 CD8 T 细胞的发育和维持中起着关键作用。在这篇综述中，我们总结了整合素介导的组织特异性 TGF-β 激活及其对 CD103 CD8 T 细胞发育和维持的贡献的最新认识。此外，我们还讨论了 TGF-β 调节 CD103 CD8 T 细胞发育和维持的潜在机制。总的来说，这篇综述强调了 TGF-β 在调节这一独特的记忆 CD8 T 细胞亚群中的重要性，这可能为改善针对这一人群的疫苗设计提供思路。
