Montgomery Tyler H, Master Anuj P, Jin Zeng, Shi Qiongyu, Lai Qin, Desai Rohan, Zhang Weizhou, Maharjan Chandra K, Kolb Ryan
Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
UF Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.
Cells. 2025 Aug 21;14(16):1297. doi: 10.3390/cells14161297.
Tissue-resident memory T (TRM) cells have emerged as critical sentinels in the control of cancer metastasis, yet their precise roles across different tumor types and tissues remain underappreciated. Here, we review current insights into the mechanisms governing TRM cell seeding and retention in pre-metastatic niches, their effector functions in eliminating disseminated tumor cells, and their dynamic crosstalk with local stromal and myeloid populations. Here, we highlight evidence for organ-specific variability in TRM cell-mediated immunity, discuss strategies for therapeutically harnessing these cells-ranging from vaccination and checkpoint modulation to chemokine axis manipulation-and explore their promise as prognostic biomarkers. Finally, we outline key knowledge gaps and future directions aimed at translating TRM cell biology into targeted interventions to prevent and treat metastatic disease.
组织驻留记忆T（TRM）细胞已成为控制癌症转移的关键哨兵，然而它们在不同肿瘤类型和组织中的精确作用仍未得到充分认识。在这里，我们回顾了目前对TRM细胞在转移前生态位中播种和保留机制的见解，它们在消除播散肿瘤细胞中的效应功能，以及它们与局部基质和髓样细胞群体的动态相互作用。在这里，我们强调了TRM细胞介导的免疫中器官特异性变异性的证据，讨论了治疗性利用这些细胞的策略——从疫苗接种、检查点调节到趋化因子轴操纵——并探索它们作为预后生物标志物的前景。最后，我们概述了关键的知识空白和未来方向，旨在将TRM细胞生物学转化为预防和治疗转移性疾病的靶向干预措施。
