Chen Xibei, Zheng Yuxin, Man Xiaoyong, Li Wei
Department of Dermatology, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310009, China.
Chin Med J (Engl). 2025 May 20;138(10):1175-1183. doi: 10.1097/CM9.0000000000003499. Epub 2025 Mar 11.
Tissue-resident memory T (TRM) cells are a recently defined subtype of non-recirculating memory T cells with longevity and protective functions in peripheral tissues. As an essential frontline defense against infections, TRM cells have been reported to robustly patrol the tissue microenvironment in malignancies. Accumulating evidence also implicates that TRM cells in the relapse of chronic inflammatory skin diseases such as psoriasis and vitiligo. In light of these developments, this review aims to synthesize these recent findings to enhance our understanding of TRM cell characteristics and actions. Therefore, after providing a brief overview of the general features of the TRM cells, including precursors, homing, retention, and maintenance, we discuss recent insights gained into their heterogeneous functions in skin diseases. Specifically, we explore their involvement in conditions such as psoriasis, vitiligo, fixed drug eruption - dermatological manifestations of drug reactions at the same spot, cutaneous T cell lymphoma, and melanoma. By integrating these diverse perspectives, this review develops a comprehensive model of TRM cell behavior in various skin-related pathologies. In conclusion, our review emphasizes that deciphering the characteristics and mechanisms of TRM cell actions holds potential not only for discovering methods to slow cancer growth but also for reducing the frequency of recurrent chronic inflammation in skin tissue.
组织驻留记忆T（TRM）细胞是最近定义的一种非循环记忆T细胞亚型，在外周组织中具有长寿和保护功能。作为抵御感染的重要一线防御细胞，据报道TRM细胞在恶性肿瘤中能有力地巡视组织微环境。越来越多的证据还表明，TRM细胞与银屑病和白癜风等慢性炎症性皮肤病的复发有关。鉴于这些进展，本综述旨在综合这些最新发现，以加深我们对TRM细胞特征和作用的理解。因此，在简要概述TRM细胞的一般特征，包括前体、归巢、滞留和维持之后，我们讨论了最近对其在皮肤病中异质性功能的见解。具体而言，我们探讨了它们在银屑病、白癜风、固定性药疹（药物反应在同一部位的皮肤表现）、皮肤T细胞淋巴瘤和黑色素瘤等疾病中的作用。通过整合这些不同的观点，本综述建立了一个TRM细胞在各种皮肤相关病理中的综合行为模型。总之，我们的综述强调，解读TRM细胞作用的特征和机制不仅有望发现减缓癌症生长的方法，还能降低皮肤组织中慢性炎症复发的频率。
