Division of Transplantation, Hiram C. Polk Jr. MD Department of Surgery, University of Louisville, Louisville, Kentucky, USA.
Nutr Clin Pract. 2021 Apr;36(2):385-397. doi: 10.1002/ncp.10578. Epub 2020 Oct 1.
Pancreatic islet transplantation is a reliable approach for treating insulin-deficient diabetes. This established β-cell replacement approach has shown considerable improvements in the last 2 decades. It has helped achieve metabolic homeostasis and safe outcomes for a subset of patients with type 1 diabetes and severe pancreatitis. Nutrition support, until recently, was considered as a secondary factor, merely identified as a means of providing all the necessary nutrients for such patients. However, new literature suggests that several factors, such as the route, timing, quantity, and composition of all the nutrients administered, have key disease-altering properties and are vital during the perioperative management of such patients. This review will highlight the benefits of performing the clinical islet transplantation on a subgroup of patients with type 1 diabetes and pancreatitis and summarize new data that identify the pivotal role of nutrition support as a critical intervention in their management.
胰岛移植是治疗胰岛素缺乏型糖尿病的一种可靠方法。这种已确立的β细胞替代方法在过去 20 年中取得了相当大的进展。它帮助一部分 1 型糖尿病和重症胰腺炎患者实现了代谢平衡和安全的结果。直到最近，营养支持才被认为是次要因素，仅仅被认为是为这些患者提供所有必要营养的一种手段。然而，新的文献表明，几种因素，如途径、时间、数量和给予的所有营养素的组成，具有改变疾病的关键特性，在这些患者的围手术期管理中至关重要。这篇综述将强调对 1 型糖尿病和胰腺炎亚组患者进行临床胰岛移植的益处，并总结新的数据，这些数据确定了营养支持作为他们治疗中关键干预的关键作用。
