• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

半乳糖凝集素-9 在特应性皮炎中的作用：对角质形成细胞的影响。

The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.

机构信息

Programa de Pós-Graduação em Biociências, Instituto de Biociências Letras e Ciências Exatas, Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP 15054-000, Brazil.

Departamento de Morfologia e Genética, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04023-900, Brazil.

出版信息

Cells. 2021 Apr 20;10(4):947. doi: 10.3390/cells10040947.

DOI:10.3390/cells10040947
PMID:33923930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8073283/
Abstract

Galectin-9 (Gal-9) is a beta-galactoside-binding protein with a variety of biological functions related to immune response. However, in allergic diseases, its mechanism of action is not fully understood. This study evaluates the expression pattern of Gal-9 in patients with atopic dermatitis (AD), in ovalbumin (OVA)-induced experimental atopic dermatitis (AD) in mice, as well as its effect on human keratinocytes. The skin of OVA-immunized BALB/c mice was challenged with drops containing OVA on days 11, 14-18, and 21-24. HaCaT cells were cultured in the following experimental conditions: control (growth medium only) or stimulated with TNF-α/IFN-γ, or IL-4, or IL-17 with or without Gal-9 treatment. AD was characterized by increased levels of Gal-9 in mouse and human skin, especially in the epidermis, and with a marked influx of Gal-9 positive eosinophils and mast cells compared to the control group. Gal-9 showed an immunomodulatory effect on keratinocytes by decreasing the release of IL-6 by IL-4-stimulated keratinocytes or increasing the IL-6 and RANTES levels by IL-17- or TNF-α/IFN-γ-stimulated cells, respectively. Under IL-17, Gal-9 treatment also altered the proliferation rate of cells. Overall, increased levels of Gal-9 in AD skin contribute to the control of inflammatory response and the proliferative process of keratinocytes, suggesting this lectin as a relevant therapeutic target.

摘要

半乳糖凝集素-9（Gal-9）是一种具有多种与免疫反应相关的生物学功能的β-半乳糖苷结合蛋白。然而，在过敏性疾病中，其作用机制尚不完全清楚。本研究评估了 Gal-9 在特应性皮炎（AD）患者中的表达模式，在卵清蛋白（OVA）诱导的实验性 AD 小鼠中，以及其对人角质形成细胞的作用。用含有 OVA 的滴剂对 OVA 免疫的 BALB/c 小鼠的皮肤进行攻击，在第 11、14-18 和 21-24 天进行。HaCaT 细胞在以下实验条件下培养：对照（仅生长培养基）或用 TNF-α/IFN-γ、IL-4、IL-17 刺激，或用 Gal-9 处理。与对照组相比，AD 表现为小鼠和人皮肤中 Gal-9 水平升高，尤其是表皮，并且 Gal-9 阳性嗜酸性粒细胞和肥大细胞明显增多。Gal-9 通过减少由 IL-4 刺激的角质形成细胞释放的 IL-6，或分别通过 IL-17 或 TNF-α/IFN-γ 刺激的细胞增加 IL-6 和 RANTES 水平，对角质形成细胞具有免疫调节作用。在 IL-17 下，Gal-9 处理还改变了细胞的增殖率。总体而言，AD 皮肤中 Gal-9 水平的升高有助于控制炎症反应和角质形成细胞的增殖过程，表明该凝集素作为一个相关的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/b55add4c6188/cells-10-00947-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/f3b4f6de3dd3/cells-10-00947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/ba93e29710b2/cells-10-00947-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/baa2df9a4fcf/cells-10-00947-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/f527f5d88ad0/cells-10-00947-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/63182d46e96c/cells-10-00947-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/e7bb243c28bc/cells-10-00947-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/b55add4c6188/cells-10-00947-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/f3b4f6de3dd3/cells-10-00947-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/ba93e29710b2/cells-10-00947-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/baa2df9a4fcf/cells-10-00947-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/f527f5d88ad0/cells-10-00947-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/63182d46e96c/cells-10-00947-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/e7bb243c28bc/cells-10-00947-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4789/8073283/b55add4c6188/cells-10-00947-g007.jpg

相似文献

1
The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.半乳糖凝集素-9 在特应性皮炎中的作用：对角质形成细胞的影响。
Cells. 2021 Apr 20;10(4):947. doi: 10.3390/cells10040947.
2
Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis.半乳糖凝集素-7在特应性皮炎皮肤屏障损伤中的保护作用。
Clin Exp Allergy. 2020 Aug;50(8):922-931. doi: 10.1111/cea.13672. Epub 2020 Jun 14.
3
Anti-inflammatory effect of galectin-1 in a murine model of atopic dermatitis.半乳糖凝集素-1 在特应性皮炎小鼠模型中的抗炎作用。
J Mol Med (Berl). 2017 Sep;95(9):1005-1015. doi: 10.1007/s00109-017-1566-9. Epub 2017 Jun 29.
4
Expression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis.半乳糖凝集素-1 和半乳糖凝集素-3 在特应性皮炎和银屑病中的表达模式及免疫调节作用。
Inflammation. 2022 Jun;45(3):1133-1145. doi: 10.1007/s10753-021-01608-7. Epub 2022 Jan 15.
5
Bakuchicin attenuates atopic skin inflammation.补骨脂素可减轻特应性皮炎皮肤炎症。
Biomed Pharmacother. 2020 Sep;129:110466. doi: 10.1016/j.biopha.2020.110466. Epub 2020 Jul 1.
6
Jageum-Jung improves 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice and suppresses pro-inflammatory chemokine production by inhibiting TNF-α/IFN-γ-induced STAT-1 and NFκB signaling in HaCaT cells.Jageum-Jung 改善了二硝基氯苯诱导的小鼠特应性皮炎样皮肤损伤，并通过抑制 TNF-α/IFN-γ 诱导的 HaCaT 细胞中的 STAT-1 和 NFκB 信号通路来抑制促炎趋化因子的产生。
J Ethnopharmacol. 2018 Jul 15;221:48-55. doi: 10.1016/j.jep.2018.04.016. Epub 2018 Apr 14.
7
Korean red ginseng water extract alleviates atopic dermatitis-like inflammatory responses by negative regulation of mitogen-activated protein kinase signaling pathway in vivo.韩国红参水提取物通过体内负调控丝裂原活化蛋白激酶信号通路缓解特应性皮炎样炎症反应。
Biomed Pharmacother. 2019 Sep;117:109066. doi: 10.1016/j.biopha.2019.109066. Epub 2019 Jun 19.
8
Keratinocytes from patients with atopic dermatitis and psoriasis show a distinct chemokine production profile in response to T cell-derived cytokines.特应性皮炎和银屑病患者的角质形成细胞在对T细胞衍生细胞因子的反应中表现出独特的趋化因子产生谱。
J Allergy Clin Immunol. 2001 May;107(5):871-7. doi: 10.1067/mai.2001.114707.
9
The prevention of TNF-α/IFN-γ mixture-induced inflammation in human keratinocyte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water.矿物平衡深海盐水对 TNF-α/IFN-γ 混合物诱导的人角质形成细胞炎症和 Nc/Nga 小鼠特应性皮炎样皮肤损伤的预防作用。
Biomed Pharmacother. 2018 Jan;97:1331-1340. doi: 10.1016/j.biopha.2017.11.056. Epub 2017 Nov 14.
10
MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes.miR-146a 通过抑制角质形成细胞固有免疫反应缓解特应性皮炎的慢性皮肤炎症。
J Allergy Clin Immunol. 2014 Oct;134(4):836-847.e11. doi: 10.1016/j.jaci.2014.05.022. Epub 2014 Jul 2.

引用本文的文献

1
Galectin-9: diverse roles in skin disease.半乳糖凝集素-9：在皮肤病中的多种作用。
Front Allergy. 2025 Jul 16;6:1614277. doi: 10.3389/falgy.2025.1614277. eCollection 2025.
2
The role of galectins in the regulation of autophagy and inflammasome in host immunity.半乳糖凝集素在宿主免疫中自噬和炎性体调节中的作用。
Semin Immunopathol. 2024 Jul 23;46(3-4):6. doi: 10.1007/s00281-024-01018-5.
3
Design and Evaluation of Paeonol-Loaded Liposomes in Thermoreversible Gels for Atopic Dermatitis.用于特应性皮炎的载丹皮酚脂质体在热可逆凝胶中的设计与评价

本文引用的文献

1
Biological Therapies for Atopic Dermatitis: A Systematic Review.特应性皮炎的生物疗法：系统评价。
Dermatology. 2021;237(4):542-552. doi: 10.1159/000514535. Epub 2021 Mar 18.
2
Keratinocytes: innate immune cells in atopic dermatitis.角质形成细胞：特应性皮炎中的固有免疫细胞。
Clin Exp Immunol. 2021 Jun;204(3):296-309. doi: 10.1111/cei.13575. Epub 2021 Feb 15.
3
Galectin-9 Induced by Dietary Probiotic Mixture Regulates Immune Balance to Reduce Atopic Dermatitis Symptoms in Mice.膳食益生菌混合物诱导的半乳糖凝集素-9 调节免疫平衡，减轻小鼠特应性皮炎症状。
Gels. 2023 Mar 5;9(3):198. doi: 10.3390/gels9030198.
Front Immunol. 2020 Jan 22;10:3063. doi: 10.3389/fimmu.2019.03063. eCollection 2019.
4
Role of Galectin-9 in Atopic Dermatitis - Is It Mediated Through E Selectin? A Clinical and Immunohistochemical Study.半乳糖凝集素-9在特应性皮炎中的作用——它是通过E选择素介导的吗？一项临床和免疫组织化学研究。
Clin Cosmet Investig Dermatol. 2020 Jan 10;13:11-19. doi: 10.2147/CCID.S229393. eCollection 2020.
5
The epithelial immune microenvironment (EIME) in atopic dermatitis and psoriasis.特应性皮炎和银屑病的上皮免疫微环境 (EIME)。
Nat Immunol. 2018 Dec;19(12):1286-1298. doi: 10.1038/s41590-018-0256-2. Epub 2018 Nov 16.
6
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis.度普利尤单抗可改善特应性皮炎患者的全身性和皮肤异常。
J Allergy Clin Immunol. 2019 Jan;143(1):155-172. doi: 10.1016/j.jaci.2018.08.022. Epub 2018 Sep 5.
7
Galectins: Multitask signaling molecules linking fibroblast, endothelial and immune cell programs in the tumor microenvironment.半乳糖凝集素：连接肿瘤微环境中成纤维细胞、内皮细胞和免疫细胞程序的多功能信号分子。
Cell Immunol. 2018 Nov;333:34-45. doi: 10.1016/j.cellimm.2018.03.008. Epub 2018 Mar 21.
8
Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?特应性皮炎和银屑病：两种不同的免疫性疾病，还是同一疾病谱？
Curr Opin Immunol. 2017 Oct;48:68-73. doi: 10.1016/j.coi.2017.08.008. Epub 2017 Sep 1.
9
Anti-inflammatory effect of galectin-1 in a murine model of atopic dermatitis.半乳糖凝集素-1 在特应性皮炎小鼠模型中的抗炎作用。
J Mol Med (Berl). 2017 Sep;95(9):1005-1015. doi: 10.1007/s00109-017-1566-9. Epub 2017 Jun 29.
10
The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies.特应性皮炎的免疫学及其通过广谱和靶向治疗的可逆性。
J Allergy Clin Immunol. 2017 Apr;139(4S):S65-S76. doi: 10.1016/j.jaci.2017.01.011.