Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.
Semin Immunopathol. 2024 Jul 23;46(3-4):6. doi: 10.1007/s00281-024-01018-5.
Galectins, a family of glycan-binding proteins have been shown to bind a wide range of glycans. In the cytoplasm, these glycans can be endogenous (or "self"), originating from damaged endocytic vesicles, or exogenous (or "non-self"), found on the surface of invading microbial pathogens. Galectins can detect these unusual cytosolic exposures to glycans and serve as critical regulators in orchestrating immune responses in innate and adaptive immunity. This review provides an overview of how galectins modulate host cellular responses, such as autophagy, xenophagy, and inflammasome-dependent cell death program, to infection.
半乳糖凝集素是一类糖结合蛋白家族，已被证实能结合广泛的糖链。在细胞质中，这些糖链可以是内源性（或“自身”）的，来源于受损的内吞小泡，也可以是外源性（或“非自身”）的，存在于入侵的微生物病原体表面。半乳糖凝集素可以检测到这些细胞内糖链的异常暴露，并在先天免疫和适应性免疫中作为关键的调节因子来协调免疫反应。本综述概述了半乳糖凝集素如何调节宿主细胞对感染的反应，如自噬、异噬和炎性小体依赖性细胞死亡程序。
