Whitley R J, Corey L, Arvin A, Lakeman F D, Sumaya C V, Wright P F, Dunkle L M, Steele R W, Soong S J, Nahmias A J
University of Alabama at Birmingham 35294.
J Infect Dis. 1988 Jul;158(1):109-16. doi: 10.1093/infdis/158.1.109.
We compared the clinical presentation of 95 newborns with herpes simplex virus (HSV) infection from 1973 through 1981 (first period) with data from 196 newborns evaluated from 1982 through 1987 (second period). There was a significant change in the presentation of infection in these infants. From the first to the second period, the frequency of disseminated disease decreased from 50.5% to 22.9%, whereas the frequency of skin, eye, and mouth (SEM) diseases increased from 17.9% to 43.4% (P less than .001). The frequency of infants with central nervous system (CNS) disease remained relatively unchanged--31.6% versus 33.7%. We also compared the demographic and clinical characteristics of the infants and their mothers. For neonates with CNS or disseminated infection, disease duration and frequency of prematurity were significantly decreased in the second period, as was the frequency of skin vesicles for newborns with SEM or disseminated infection. These changes are most likely the consequence of recognizing and treating SEM infection before its progression to more-severe disease.
我们将1973年至1981年期间（第一阶段）95例感染单纯疱疹病毒（HSV）的新生儿的临床表现与1982年至1987年期间（第二阶段）评估的196例新生儿的数据进行了比较。这些婴儿感染的表现有显著变化。从第一阶段到第二阶段，播散性疾病的发生率从50.5%降至22.9%，而皮肤、眼和口（SEM）疾病的发生率从17.9%增至43.4%（P＜0.001）。患有中枢神经系统（CNS）疾病的婴儿发生率相对未变，分别为31.6%和33.7%。我们还比较了婴儿及其母亲的人口统计学和临床特征。对于患有CNS或播散性感染的新生儿，第二阶段的疾病持续时间和早产发生率显著降低，患有SEM或播散性感染的新生儿皮肤水疱发生率也降低。这些变化很可能是在SEM感染进展为更严重疾病之前就对其进行识别和治疗的结果。
