Chen Nellie, Kilpatrick Ryan, VerHage Erik J, Smith P Brian, Bukhari Areej, Hornik Chi D, Tolia Veeral N, Benjamin Daniel K, Greenberg Rachel G
Duke University School of Medicine, Durham, NC, USA.
Division of Newborn Medicine, Tufts University School of Medicine, Boston, MA, USA.
J Perinatol. 2025 Jan;45(1):116-121. doi: 10.1038/s41372-024-02150-8. Epub 2024 Oct 11.
Describe the epidemiology and clinical characteristics of infants in the neonatal intensive care unit (NICU) with acyclovir exposure and herpes simplex virus (HSV) infection.
Our primary analysis was to evaluate the prevalence of HSV infection among infants in the NICU who received acyclovir. We compared characteristics of infants with and without HSV and used multivariable regression analyses to assess associations between infection and clinical outcomes.
Of 1,057,061 infants, 17,910 (2%) received acyclovir. Of those who received acyclovir, 1090 (5%) had HSV. Infection was associated with lower gestational age and lower birth weight. Multivariable models demonstrated that infected infants had higher mortality, greater postmenstrual age at discharge, and longer length of stay.
Infants in the NICU who received acyclovir and have HSV are more likely to be born at lower gestational age, have lower birth weight, and have higher morbidities and mortality.
描述新生儿重症监护病房（NICU）中接受阿昔洛韦治疗且感染单纯疱疹病毒（HSV）的婴儿的流行病学特征和临床特点。
我们的主要分析是评估NICU中接受阿昔洛韦治疗的婴儿中HSV感染的患病率。我们比较了感染HSV和未感染HSV的婴儿的特征，并使用多变量回归分析来评估感染与临床结局之间的关联。
在1,057,061名婴儿中，17,910名（2%）接受了阿昔洛韦治疗。在接受阿昔洛韦治疗的婴儿中，1090名（5%）感染了HSV。感染与较低的胎龄和较低的出生体重相关。多变量模型显示，感染婴儿的死亡率更高，出院时的孕龄更大，住院时间更长。
NICU中接受阿昔洛韦治疗且感染HSV的婴儿更有可能出生时胎龄较小、出生体重较低，且发病率和死亡率较高。
