Chizenga Elvin Peter, Abrahamse Heidi
Laser Research Centre, University of Johannesburg, Johannesburg 2028, South Africa.
Pharmaceutics. 2021 Apr 28;13(5):626. doi: 10.3390/pharmaceutics13050626.
Good medicine is based on good science, inquiry driven and open to new paradigms. For a complex disease such as cancer, a complex treatment regime that is well structured and multifactorial is indispensable. In the present day, Complementary and Alternative Medicine (CAM) therapies are being used frequently for cancer, alongside modern biological therapies and allopathic medicine, in what is called integrative oncology. In all conscience, the use of natural, less invasive interventions whenever possible is ideal. However, a comprehensive understanding of not only the etiopathology of individual cancers, but also the detailed genetic and epigenetic characteristics, the cancer hallmarks, that clearly show the blueprint of the cancer phenotype is a requisite. Different tumors have a common behavioral pattern, but their specific features at the genetic and epigenetic levels vary to a great extent. Henceforth, with so many failed attempts to therapy, drug formulations and combinations need a focused pre-assessment of the inherent features of individual cancers to destroy the tumors holistically by targeting these features. This review therefore presents innocuous therapeutic regimes by means of CAM and integrative medicine approaches that can specifically target the hallmarks of cancer, using the case of cervical cancer.
好的医学基于良好的科学，以探究为驱动并接纳新的范式。对于像癌症这样的复杂疾病，一个结构合理且多因素的复杂治疗方案是必不可少的。如今，在所谓的整合肿瘤学中，补充和替代医学（CAM）疗法经常与现代生物疗法和对抗疗法一起用于癌症治疗。凭良心说，尽可能使用天然、侵入性较小的干预措施是理想的。然而，不仅要全面了解个体癌症的病因病理学，还要详细了解清楚显示癌症表型蓝图的基因和表观遗传特征，即癌症标志。不同的肿瘤有共同的行为模式，但它们在基因和表观遗传水平上的特定特征差异很大。从今往后，由于治疗、药物配方和联合用药有如此多失败的尝试，需要对个体癌症的固有特征进行有针对性的预先评估，以便通过针对这些特征全面摧毁肿瘤。因此，本综述通过CAM和整合医学方法介绍了无害的治疗方案，这些方案可以以宫颈癌为例，专门针对癌症标志。
