喉鳞状细胞癌肿瘤微环境中的肿瘤浸润淋巴细胞：系统评价与Meta分析

Tumor-Infiltrating Lymphocytes in the Tumor Microenvironment of Laryngeal Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.

作者信息

Rodrigo Juan P, Sánchez-Canteli Mario, López Fernando, Wolf Gregory T, Hernández-Prera Juan C, Williams Michelle D, Willems Stefan M, Franchi Alessandro, Coca-Pelaz Andrés, Ferlito Alfio

机构信息

Department of Otolaryngology, Hospital Universitario Central de Asturias-Instituto de Salud del Principado de Asturias (ISPA), 33011 Oviedo, Spain.

IUOPA-University of Oviedo, 33006 Oviedo, Spain.

出版信息

Biomedicines. 2021 Apr 28;9(5):486. doi: 10.3390/biomedicines9050486.

The presence of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment has been demonstrated to be of prognostic value in various cancers. In this systematic review and meta-analysis, we investigated the prognostic value of TIL in laryngeal squamous cell carcinoma (LSCC). We performed a systematic search in PubMed for publications that investigated the prognostic value of TIL in LSCC. A meta-analysis was performed including all studies assessing the association between TIL counts in hematoxylin-eosin (HE)-stained sections, for CD8+ and/or CD3+/CD4+ TIL and overall survival (OS) or disease-free survival (DFS). The pooled meta-analysis showed a favorable prognostic role for stromal TIL in HE sections for OS (HR 0.57, 95% CI 0.36-0.91, = 0.02), and for DFS (HR 0.56, 95% CI 0.34-0.94, = 0.03). High CD8+ TIL were associated with a prolonged OS (HR 0.62, 95% CI 0.4-0.97, = 0.04) and DFS (HR 0.73, 95% CI 0.34-0.94, = 0.002). High CD3+/CD4+ TIL demonstrated improved OS (HR 0.32, 95% CI 0.16-0.9, = 0.03) and DFS (HR 0.23, 95% CI 0.10-0.53, = 0.0005). This meta-analysis confirmed the favorable prognostic significance of TIL in LSCC. High stromal TIL evaluated in HE sections and intra-tumoral and stromal CD3+, CD4+ and/or CD8+ TIL might predict a better clinical outcome.

肿瘤微环境中肿瘤浸润淋巴细胞（TIL）的存在已被证明在多种癌症中具有预后价值。在这项系统评价和荟萃分析中，我们研究了TIL在喉鳞状细胞癌（LSCC）中的预后价值。我们在PubMed中进行了系统检索，以查找研究TIL在LSCC中预后价值的出版物。进行了一项荟萃分析，纳入了所有评估苏木精-伊红（HE）染色切片中CD8 +和/或CD3 + / CD4 + TIL计数与总生存期（OS）或无病生存期（DFS）之间关联的研究。汇总的荟萃分析显示，HE切片中基质TIL对OS具有良好的预后作用（HR 0.57，95％CI 0.36-0.91，P = 0.02），对DFS也有良好预后作用（HR 0.56，95％CI 0.34-0.94，P = 0.03）。高CD8 + TIL与延长的OS（HR 0.62，95％CI 0.4-0.97，P = 0.04）和DFS（HR 0.73，95％CI 0.34-0.94，P = 0.002）相关。高CD3 + / CD4 + TIL显示OS改善（HR 0.32，95％CI 0.16-0.9，P = 0.03）和DFS改善（HR 0.23，95％CI 0.10-0.53，P = 0.0005）。这项荟萃分析证实了TIL在LSCC中的良好预后意义。在HE切片中评估的高基质TIL以及肿瘤内和基质CD3 +、CD4 +和/或CD8 + TIL可能预示着更好的临床结局。