Department of Microbiology and Plant Pathology, University of California, Riverside, CA 92521, USA.
Viruses. 2021 Apr 27;13(5):763. doi: 10.3390/v13050763.
Flaviviruses implement a broad range of antagonism strategies against the host antiviral response. A pivotal component of the early host response is production and signaling of type I interferon (IFN-I). Ubiquitin, a prevalent cellular protein-modifying molecule, is heavily involved in the cellular regulation of this and other immune response pathways. Viruses use ubiquitin and ubiquitin machinery to antagonize various steps of these pathways through diverse mechanisms. Here, we highlight ways in which flaviviruses use or inhibit ubiquitin to antagonize the antiviral IFN-I response.
黄病毒针对宿主抗病毒反应实施了广泛的拮抗策略。宿主早期反应的一个关键组成部分是 I 型干扰素（IFN-I）的产生和信号转导。泛素是一种普遍存在的细胞蛋白修饰分子，它在这些和其他免疫反应途径的细胞调控中起着重要作用。病毒利用泛素和泛素机制通过多种机制来拮抗这些途径的各个步骤。在这里，我们强调了黄病毒利用或抑制泛素来拮抗抗病毒 IFN-I 反应的方式。
