Faculty of Health and Life Sciences, Northumbria University Newcastle, Newcastle upon Tyne NE1 8ST, UK.
Pulmonology Department, Lung Cancer and Muscle Research Group, Hospital del Mar-IMIM, Parc de Salut Mar, Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), CIBERES, 08002 Barcelona, Spain.
Cells. 2021 Apr 26;10(5):1022. doi: 10.3390/cells10051022.
Exercise training promotes muscle adaptation and remodelling by balancing the processes of anabolism and catabolism; however, the mechanisms by which exercise delays accelerated muscle wasting are not fully understood. Intramuscular extracellular matrix (ECM) proteins are essential to tissue structure and function, as they create a responsive environment for the survival and repair of the muscle fibres. However, their role in muscle adaptation is underappreciated and underinvestigated. The PubMed, COCHRANE, Scopus and CIHNAL databases were systematically searched from inception until February 2021. The inclusion criteria were on ECM adaptation after exercise training in healthy adult population. Evidence from 21 studies on 402 participants demonstrates that exercise training induces muscle remodelling, and this is accompanied by ECM adaptation. All types of exercise interventions promoted a widespread increase in collagens, glycoproteins and proteoglycans ECM transcriptomes in younger and older participants. The ECM controlling mechanisms highlighted here were concerned with myogenic and angiogenic processes during muscle adaptation and remodelling. Further research identifying the mechanisms underlying the link between ECMs and muscle adaptation will support the discovery of novel therapeutic targets and the development of personalised exercise training medicine.
运动训练通过平衡合成代谢和分解代谢过程来促进肌肉适应和重塑；然而，运动延缓加速肌肉消耗的机制尚不完全清楚。肌内细胞外基质 (ECM) 蛋白对于组织结构和功能至关重要，因为它们为肌肉纤维的存活和修复创造了一个响应环境。然而，它们在肌肉适应中的作用尚未得到充分认识和研究。从 2021 年 2 月开始，系统地在 PubMed、COCHRANE、Scopus 和 CIHNAL 数据库中进行了检索。纳入标准为健康成年人群中运动训练后的 ECM 适应性。来自 21 项研究 402 名参与者的证据表明，运动训练可诱导肌肉重塑，同时伴随着 ECM 适应性。所有类型的运动干预都促进了年轻和老年参与者的胶原蛋白、糖蛋白和蛋白聚糖 ECM 转录组的广泛增加。这里强调的 ECM 控制机制与肌肉适应和重塑过程中的成肌和血管生成过程有关。进一步研究确定 ECM 和肌肉适应之间联系的机制将支持发现新的治疗靶点和个性化运动训练医学的发展。
