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三维打印多孔植入物联合自体骨重建治疗胫骨近端骨巨细胞瘤。

Three-dimensional-printed porous implant combined with autograft reconstruction for giant cell tumor in proximal tibia.

机构信息

Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guoxuexiang, Chengdu, 610041, Sichuan, People's Republic of China.

Bone and Joint 3D-Printing & Biomechanical Laboratory, Department of Orthopedics, West China Hospital, Sichuan University, No. 37 Guoxuexiang, Chengdu, 610041, Sichuan, People's Republic of China.

出版信息

J Orthop Surg Res. 2021 Apr 29;16(1):286. doi: 10.1186/s13018-021-02446-x.

Abstract

BACKGROUND

This study is to describe the design and surgical techniques of three- dimensional-printed porous implants for proximal giant cell tumors of bone and evaluate the short-term clinical outcomes.

METHODS

From December 2016 to April 2020, 8 patients with giant cell tumor of bone in the proximal tibia underwent intralesional curettage of the tumor and reconstruction with bone grafting and three-dimensional-printed porous implant. Detailed anatomy data were measured, including the size of lesion and thickness of the subchondral bone. Prostheses were custom-made for each patient by our team. All patients were evaluated regularly and short-term clinical outcomes were recorded.

RESULTS

The mean follow-up period was 26 months. According to the different defect sizes, the mean size of the plate and mean length of strut were 35 × 35 mm and 20 mm, respectively. The mean affected subchondral bone percentage was 31.5%. The average preoperative and postoperative thickness of the subchondral bone was 2.1 mm and 11.1 mm, respectively. There was no wound infection, skin necrosis, peroneal nerve injury, or other surgical related complications. No degeneration of the knee joint was found. Osseointegration was observed in all patients. The MSTS improved from an average of 12 preoperatively to 28 postoperatively.

CONCLUSION

The application of three-dimensional-printed printed porous prosthesis combined autograft could supply enough mechanical support and enhance bone ingrowth. The design and operation management lead to satisfactory subchondral bone reconstruction.

摘要

背景

本研究旨在描述用于骨近端骨巨细胞瘤的三维打印多孔植入物的设计和手术技术,并评估其短期临床结果。

方法

自 2016 年 12 月至 2020 年 4 月,8 例胫骨近端骨巨细胞瘤患者接受肿瘤内切除术,并用骨移植和三维打印多孔植入物重建。测量详细的解剖数据,包括病变大小和软骨下骨厚度。我们团队为每位患者定制了假体。所有患者均定期进行评估,并记录短期临床结果。

结果

平均随访时间为 26 个月。根据不同的缺损大小,板的平均尺寸和支柱的平均长度分别为 35×35mm 和 20mm。受影响的软骨下骨百分比平均为 31.5%。软骨下骨的平均术前和术后厚度分别为 2.1mm 和 11.1mm。无伤口感染、皮肤坏死、腓总神经损伤或其他与手术相关的并发症。未发现膝关节退变。所有患者均观察到骨整合。MSTS 从术前平均 12 分提高到术后 28 分。

结论

三维打印多孔假体联合自体移植物的应用可为提供足够的机械支撑和增强骨内生长。设计和手术管理导致软骨下骨重建令人满意。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe6b/8082833/86bdc86ea06f/13018_2021_2446_Fig1_HTML.jpg

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