脑肿瘤的单光子发射计算机断层扫描和正电子发射断层扫描的细胞和分子成像。
Cellular and Molecular Imaging with SPECT and PET in Brain Tumors.
机构信息
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3150, Baltimore, MD 21287, USA.
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3150, Baltimore, MD 21287, USA.
出版信息
Radiol Clin North Am. 2021 May;59(3):363-375. doi: 10.1016/j.rcl.2021.01.005.
This review highlights the 2 major molecular imaging modalities that are used in clinics, namely single-photon emission computed tomography (SPECT) and positron emission tomography (PET), and their added value in management of patients with brain tumors. There are a variety of SPECT and PET radiotracers that can allow imaging of different molecular processes. Those radiotracers target specific molecular features of tumors, resulting in improved specificity of these agents. Potential applications include staging of brain tumors and evaluating post-therapeutic changes.
这篇综述重点介绍了两种在临床上使用的主要分子成像方式，即单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET），以及它们在脑肿瘤患者管理中的附加值。有多种 SPECT 和 PET 放射性示踪剂可用于对不同的分子过程进行成像。这些放射性示踪剂针对肿瘤的特定分子特征，从而提高了这些药物的特异性。潜在的应用包括脑肿瘤分期和评估治疗后变化。
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