Relaxant Effects of the Aqueous Extract of (Euphorbiaceae) Leaves on Uterine Horn Contractility in Wistar Rats.

In uterine smooth muscle, the effects of are not yet documented. To fill this gap, we investigated the pharmacological effect of on the contraction of the rat isolated uterine horns. The isolated segments were exposed to different concentrations of the aqueous extract of leaves and pharmacological drugs. The results showed that aqueous extract decreased the amplitude and frequency by concentration-related manner. IC values were 2.4 and 2.6, respectively, for amplitude and frequency. Our study revealed that the extract did not act through histamine H-receptors or the nitric oxide pathway. It also inhibited uterine contractions induced by oxytocin and potassium chloride (KCl). These data suggest that active compound can be used for calming uterine contractions. The action of showed that it can be useful to fight against diseases which caused uterotonic effects. It can be useful to prevent preterm birth and pains caused by menstruations but further investigation is needed to clarify the mechanism action.