Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Ther Apher Dial. 2022 Feb;26(1):55-63. doi: 10.1111/1744-9987.13665. Epub 2021 May 19.
The characteristics in dialyzer are associated with mortality in patients with end-stage renal disease (ESRD) receiving hemodialysis (HD). This study is to investigate the effects of dialyzer membranes on 3-year mortality in ESRD patients. From the long-term nationwide population database. Prevalent HD patients during 2005-2012 were enrolled. Our main analysis to calculate the effect was cox regression multivariate model. Overall, the mean age of all population (N = 73 565) was 61.0 ± 13.6 years, the observation period is 2.46 years ±0.98 within 3 years and 64.6% used polysulfone (PS), polymethyl methacrylate (PMMA) (11.6%), polyethersulfone (11.4%), and cellulose triacetate (CTA) (10.7%), ethylene vinyl alcohol (EVAL) (hazard ratio [HR] 2.72, 95% confidence interval [CI] 1.71-4.33) and CTA (HR 1.35, 95% CI 1.12-1.64) were associated with higher mortality than PS, but PMMA was not. EVAL and CTA adversely affected mortality and PMMA had no protective role. Further investigations on membrane characters on HD patients are warranted. Taipei Medical University (TMU) (TMU-JIRB (No. N201804051).
在接受血液透析 (HD) 的终末期肾脏疾病 (ESRD) 患者中，透析器的特性与死亡率相关。本研究旨在探讨透析器膜对 ESRD 患者 3 年死亡率的影响。该研究从长期全国人口数据库中招募了 2005 年至 2012 年期间的 HD 患者。我们主要采用 Cox 回归多变量模型来计算效应。总体而言，所有人群（N=73565）的平均年龄为 61.0±13.6 岁，观察期为 3 年内 2.46 年±0.98 年，64.6%的患者使用聚砜 (PS)、聚甲基丙烯酸甲酯 (PMMA) (11.6%)、聚醚砜 (11.4%) 和醋酸纤维素三乙酸酯 (CTA) (10.7%)、乙烯-乙烯醇 (EVAL) (风险比 [HR] 2.72，95%置信区间 [CI] 1.71-4.33) 和 CTA (HR 1.35，95% CI 1.12-1.64)与 PS 相比，死亡率更高，但 PMMA 则不然。EVAL 和 CTA 对死亡率有不利影响，而 PMMA 则没有保护作用。需要进一步研究 HD 患者膜特性。台北医学大学 (TMU) (TMU-JIRB（编号 N201804051）。
