Department of Obstetrics and Gynecology, Seventh Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Center of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
PLoS One. 2021 Apr 30;16(4):e0250943. doi: 10.1371/journal.pone.0250943. eCollection 2021.
The collagen 3 alpha 1 (COL3A1) rs1800255 polymorphism has been reported to be associated with women pelvic organ prolapse (POP) susceptibility, but the results of these previous studies have been contradictory. The objective of current study is to explore whether COL3A1 rs1800255 polymorphism confers risk to POP.
Relevant literatures were searched by searching databases including Pubmed, Embase, Google academic, the Cochrane library, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to March 2021.
A total of seven literatures were enrolled in the present meta-analysis, including 1642 participants. Overall, no significant association was found by any genetic models. In subgroup analysis based on ethnicity, significant associations were demonstrated in Caucasians by allele contrast (A vs. G: OR = 1.34, 95%CI = 1.03-1.74,), homozygote comparison (AA vs. GG: OR = 3.25, 95%CI = 1.39-7.59), and recessive genetic model (AA vs. GG/GA: OR = 3.22, 95%CI = 1.40-7.42).
The present meta-analysis suggests that the COL3A1 is a candidate gene for POP susceptibility. Caucasian individuals with A allele and AA genotype have a higher risk of POP. The COL3A1 rs1800255 polymorphism may be risk factor for POP in Caucasian population.
胶原 3 阿尔法 1（COL3A1）rs1800255 多态性已被报道与女性盆腔器官脱垂（POP）易感性相关，但这些先前研究的结果存在矛盾。本研究旨在探讨 COL3A1 rs1800255 多态性是否对 POP 有风险。
通过检索 Pubmed、Embase、Google 学术、Cochrane 图书馆、中国知网（CNKI）等数据库，搜索了截至 2021 年 3 月的相关文献。
本荟萃分析共纳入了 7 篇文献，包括 1642 名参与者。总体而言，任何遗传模型均未发现显著相关性。在基于种族的亚组分析中，在白种人中，等位基因对比（A 对 G：OR = 1.34，95%CI = 1.03-1.74）、纯合子比较（AA 对 GG：OR = 3.25，95%CI = 1.39-7.59）和隐性遗传模型（AA 对 GG/GA：OR = 3.22，95%CI = 1.40-7.42）均显示出显著相关性。
本荟萃分析表明，COL3A1 是 POP 易感性的候选基因。携带 A 等位基因和 AA 基因型的白种人发生 POP 的风险更高。COL3A1 rs1800255 多态性可能是白种人群 POP 的危险因素。
