Saputra Akbar Novan Dwi, Rizal Dicky Moch, Septiyorini Nandia, Rahman Muhammad Nurhadi
Doctoral Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Department of Obstetrics and Gynecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Int Urogynecol J. 2024 Nov;35(11):2097-2106. doi: 10.1007/s00192-024-05953-7. Epub 2024 Oct 1.
Changes in the expression of type III collagen have been linked to women's predisposition to pelvic organ prolapse (POP); however, the findings of prior studies have been conflicting. This study was aimed at investigating whether changes in the type III collagen gene expression levels occur in POP development.
A systematic review and meta-analysis were conducted on research articles that evaluated type III collagen gene expression levels in patients with POP compared with those without the condition. The articles, published between January 2000 and February 2024, were obtained from PubMed, ScienceDirect, Semantic Scholar, and EBSCO databases. Data were analyzed using fixed-effect models, and the pooled standardized mean difference (SMD) was calculated. Cochrane's Review Manager 5.4 was used for the analysis. The aggregated SMD with 95% confidence interval (CI) regarding type III collagen gene expression levels relative to POP development was the main outcome measure. Results with p < 0.05 were considered statistically significant.
Six studies were included in our analysis, comprising 229 POP cases and 139 non-POP cases. Our meta-analysis indicated that patients with POP had higher type III collagen gene expression levels than those without POP (SMD = 0.32; 95% CI: 0.07 to 0.56; p = 0.01).
The results of this study provide evidence that a higher type III collagen gene expression levels is significantly associated with POP.
III型胶原蛋白表达的变化与女性盆腔器官脱垂（POP）的易感性有关；然而，先前研究的结果相互矛盾。本研究旨在调查III型胶原蛋白基因表达水平的变化是否发生在POP的发展过程中。
对评估POP患者与非POP患者III型胶原蛋白基因表达水平的研究文章进行系统综述和荟萃分析。从PubMed、ScienceDirect、Semantic Scholar和EBSCO数据库中获取2000年1月至2024年2月发表的文章。使用固定效应模型分析数据，并计算合并标准化平均差（SMD）。使用Cochrane系统评价软件5.4进行分析。关于III型胶原蛋白基因表达水平相对于POP发展的汇总SMD及其95%置信区间（CI）是主要结局指标。p < 0.05的结果被认为具有统计学意义。
我们的分析纳入了六项研究，包括229例POP病例和139例非POP病例。我们的荟萃分析表明，POP患者的III型胶原蛋白基因表达水平高于非POP患者（SMD = 0.32；95% CI：0.07至0.56；p = 0.01）。
本研究结果提供了证据，表明较高的III型胶原蛋白基因表达水平与POP显著相关。
