Nuclear Engineering Program, University of Sharjah, Sharjah, 27272, United Arab Emirates.
Nuclear Engineering Program, University of Sharjah, Sharjah, 27272, United Arab Emirates.
Appl Radiat Isot. 2021 Aug;174:109742. doi: 10.1016/j.apradiso.2021.109742. Epub 2021 Apr 24.
Neutron capture therapy (NCT) is a radiotherapeutic technique that is designed to utilize the neutron capture reaction and damage the tumor cells through the energy release from the reaction. Nuclear reactors are typically utilized in this therapy because of the high neutron fluence rate that can be achieved. There has been minimal work to evaluate the effectiveness of neutron generators in NCT. This work presents the preliminary simulation results of utilizing of a deuterium-deuterium generator in boron neutron capture therapy. MCNP 6.1 was used to model the detailed geometry of the neutron generator and the phantom. Neutron moderators and photon shielding were used to optimize the neutron fluence rate in the tumor and decrease the photon dose in the phantom respectively. The study showed that a good localization of the neutron dose can be achieved in the tumor area with a reduction of the photon dose in the surrounding areas.
中子俘获治疗（NCT）是一种放射治疗技术，旨在利用中子俘获反应，通过反应释放的能量来破坏肿瘤细胞。由于可以实现高中子通量率，因此通常在该治疗中使用核反应堆。在 NCT 中，利用中子发生器的有效性评估工作很少。这项工作介绍了利用氘氘发生器进行硼中子俘获治疗的初步模拟结果。MCNP6.1 用于模拟中子发生器和模型的详细几何形状。中子减速剂和光子屏蔽分别用于优化肿瘤中的中子通量率并降低模型中的光子剂量。研究表明，可以在肿瘤区域实现良好的中子剂量定位，同时减少周围区域的光子剂量。
