Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Human Nutrition and Dietetics, National University of Medical Sciences, Islamabad, Pakistan.
Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, Nanjing, China.
Nutrition. 2021 Sep;89:111244. doi: 10.1016/j.nut.2021.111244. Epub 2021 Mar 17.
Lifestyle and genetic perturbation of circadian rhythm can trigger the incidence and severity of metabolic diseases. Time-restricted feeding (TRF) regulates the circadian rhythm of food intake that protects against metabolic disorders induced by adverse nutrient intake. TRF also executes host metabolism from nutrient availability to optimize nutrient utilization. Circadian clock and nutrient-sensing pathways coordinate to regulate metabolic health through the feeding/fasting cycle. Concurrently, TRF imposes diurnal rhythm in nutrient utilization, thereby preserving cellular homeostasis. However, modulation of daily feeding and fasting periods calibrates the circadian clock, which protects against the lethal effects of nutrient imbalance on metabolism. Therefore, TRF also improves and restores metabolic rhythms that ultimately lead to better fitness by reversing the alteration in genotype-specific gene expression. The aim of this review was to summarize that TRF is an emerging dietary approach that maintains robust circadian rhythms in support of a steady daily feeding and fasting cycle. TRF also encourages the coordination between circadian clock components and nutrient-sensing pathways via molecular effectors that exert a protective role in the prevention of metabolic diseases.
生活方式和昼夜节律的遗传干扰会引发代谢性疾病的发生和严重程度。限时进食（TRF）调节食物摄入的昼夜节律，可防止不良营养摄入引起的代谢紊乱。TRF 还可根据营养物质的可用性来执行宿主代谢，以优化营养物质的利用。昼夜节律钟和营养感应途径通过进食/禁食周期协调调节代谢健康。同时，TRF 会在营养利用中产生昼夜节律，从而维持细胞内稳态。然而，每日进食和禁食时间的调节会校准生物钟，从而防止营养失衡对代谢的致命影响。因此，TRF 还通过逆转基因型特异性基因表达的改变来改善和恢复代谢节律，从而通过逆转基因型特异性基因表达的改变来提高和恢复代谢节律，从而提高适应性。本综述的目的是总结 TRF 是一种新兴的饮食方法，它可以维持强大的昼夜节律，支持稳定的每日进食和禁食周期。TRF 还通过分子效应器促进昼夜节律钟成分和营养感应途径之间的协调，这些分子效应器在预防代谢性疾病方面发挥保护作用。
